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Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17, 20-lyase activity in vivo

BACKGROUND: 17alpha-hydroxylase/17, 20-lyase encoded by CYP17 is the key enzyme in androgen biosynthesis pathway. Previous studies demonstrated the accentuation of the enzyme in patients with polycystic ovary syndrome (PCOS) was the most important mechanism of androgen excess. We chose CYP17 as the...

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Detalles Bibliográficos
Autores principales:	Li, Yi, Liang, Xiao-yan, Wei, Li-na, Xiong, Yong-lao, Yang, Xing, Shi, Hui-gan, Yang, Zi-hong
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716347/ https://www.ncbi.nlm.nih.gov/pubmed/19615041 http://dx.doi.org/10.1186/1477-7827-7-73

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