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Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons (MN) in the brain stem and spinal cord. Intracellular disruptions of cytosolic and mitochondrial calcium have been associated with selective MN degeneration, but...

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Detalles Bibliográficos
Autores principales:	Jaiswal, Manoj Kumar, Zech, Wolf-Dieter, Goos, Miriam, Leutbecher, Christine, Ferri, Alberto, Zippelius, Annette, Carrì, Maria Teresa, Nau, Roland, Keller, Bernhard U
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716351/ https://www.ncbi.nlm.nih.gov/pubmed/19545440 http://dx.doi.org/10.1186/1471-2202-10-64

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