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The role of YY1 in reduced HP1α gene expression in invasive human breast cancer cells

INTRODUCTION: Heterochromatin protein 1 (HP1) associates with chromatin by binding to histone H3 and contributes to gene silencing. There are three isoforms of HP1 in mammals: HP1α, β, and γ. Studies have shown that the level of HP1α is reduced in invasive human breast cancer cell lines such as MDA-...

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Detalles Bibliográficos
Autores principales: Lieberthal, Jason G, Kaminsky, Marissa, Parkhurst, Christopher N, Tanese, Naoko
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716511/
https://www.ncbi.nlm.nih.gov/pubmed/19566924
http://dx.doi.org/10.1186/bcr2329

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