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Characterization of Conformation-Sensitive Antibodies to ADAMTS13, the von Willebrand Cleavage Protease

BACKGROUND: The zinc metalloprotease ADAMTS13 is a multidomain protein that cleaves von Willebrand Factor (VWF) and is implicated in Thrombotic Thrombocytopenic Purpura (TTP) pathogenesis. Understanding the mechanism of this protein is an important goal. Conformation sensitive antibodies have been u...

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Detalles Bibliográficos
Autores principales:	Sauna, Zuben E., Okunji, Chinyere, Hunt, Ryan C., Gupta, Tanvi, Allen, Courtni E., Plum, Elizabeth, Blaisdell, Adam, Grigoryan, Vahan, S, Geetha, Fathke, Robert, Soejima, Kenji, Kimchi-Sarfaty, Chava
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716513/ https://www.ncbi.nlm.nih.gov/pubmed/19654870 http://dx.doi.org/10.1371/journal.pone.0006506

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