Epidermal Growth Factor Receptor Inhibition Modulates the Microenvironment by Vascular Normalization to Improve Chemotherapy and Radiotherapy Efficacy

BACKGROUND: Epidermal growth factor receptor (EGFR) inhibitors have shown only modest clinical activity when used as single agents to treat cancers. They decrease tumor cell expression of hypoxia-inducible factor 1-α (HIF-1α) and vascular endothelial growth factor (VEGF). Hypothesizing that this mig...

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Detalles Bibliográficos
Autores principales: Cerniglia, George J., Pore, Nabendu, Tsai, Jeff H., Schultz, Susan, Mick, Rosemarie, Choe, Regine, Xing, Xiaoman, Durduran, Turgut, Yodh, Arjun G., Evans, Sydney M., Koch, Cameron J., Hahn, Stephen M., Quon, Harry, Sehgal, Chandra M., Lee, William M. F., Maity, Amit
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716529/
https://www.ncbi.nlm.nih.gov/pubmed/19657384
http://dx.doi.org/10.1371/journal.pone.0006539

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