BRCA1 Expression is an Important Biomarker for Chemosensitivity: Suppression of BRCA1 Increases the Apoptosis via Up-regulation of p53 and p21 During Cisplatin Treatment in Ovarian Cancer Cells

BRCA1 is a tumor suppressor which plays a crucial role in the repair of DNA double-strand breaks, and its abnormality is responsible for hereditary ovarian cancer syndrome. It has recently been reported that reduced expression of BRCA1 is also common in sporadic ovarian carcinoma via its promoter hy...

Descripción completa

Detalles Bibliográficos
Autores principales: Horiuchi, Akiko, Wang, Cuiju, Kikuchi, Norihiko, Osada, Ryosuke, Nikaido, Toshio, Konishi, Ikuo
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2007
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716781/
https://www.ncbi.nlm.nih.gov/pubmed/19690636

Ejemplares similares

Ejemplares similares