The effect of iron depletion on chronic hepatitis C virus infection

Increasing evidence exists that iron overload, a common finding in chronic hepatitis C virus (HCV) infection, plays an important role in the pathophysiology of this disease. The mechanisms by which iron excess induces liver damage along with the benefit of iron depletion via phlebotomy on biochemica...

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Detalles Bibliográficos
Autores principales: Franchini, Massimo, Targher, Giovanni, Capra, Franco, Montagnana, Martina, Lippi, Giuseppe
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716881/
https://www.ncbi.nlm.nih.gov/pubmed/19669262
http://dx.doi.org/10.1007/s12072-008-9076-z
Descripción
Sumario:Increasing evidence exists that iron overload, a common finding in chronic hepatitis C virus (HCV) infection, plays an important role in the pathophysiology of this disease. The mechanisms by which iron excess induces liver damage along with the benefit of iron depletion via phlebotomy on biochemical and histological outcomes in patients with chronic HCV infection have been discussed in this review. Finally, we focus on the effect of iron reduction on the rate of response to interferon antiviral therapy.

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