The effect of iron depletion on chronic hepatitis C virus infection

Increasing evidence exists that iron overload, a common finding in chronic hepatitis C virus (HCV) infection, plays an important role in the pathophysiology of this disease. The mechanisms by which iron excess induces liver damage along with the benefit of iron depletion via phlebotomy on biochemica...

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Detalles Bibliográficos
Autores principales: Franchini, Massimo, Targher, Giovanni, Capra, Franco, Montagnana, Martina, Lippi, Giuseppe
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716881/
https://www.ncbi.nlm.nih.gov/pubmed/19669262
http://dx.doi.org/10.1007/s12072-008-9076-z
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author Franchini, Massimo
Targher, Giovanni
Capra, Franco
Montagnana, Martina
Lippi, Giuseppe
author_facet Franchini, Massimo
Targher, Giovanni
Capra, Franco
Montagnana, Martina
Lippi, Giuseppe
author_sort Franchini, Massimo
collection PubMed
description Increasing evidence exists that iron overload, a common finding in chronic hepatitis C virus (HCV) infection, plays an important role in the pathophysiology of this disease. The mechanisms by which iron excess induces liver damage along with the benefit of iron depletion via phlebotomy on biochemical and histological outcomes in patients with chronic HCV infection have been discussed in this review. Finally, we focus on the effect of iron reduction on the rate of response to interferon antiviral therapy.
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spelling pubmed-27168812009-08-06 The effect of iron depletion on chronic hepatitis C virus infection Franchini, Massimo Targher, Giovanni Capra, Franco Montagnana, Martina Lippi, Giuseppe Hepatol Int Review Article Increasing evidence exists that iron overload, a common finding in chronic hepatitis C virus (HCV) infection, plays an important role in the pathophysiology of this disease. The mechanisms by which iron excess induces liver damage along with the benefit of iron depletion via phlebotomy on biochemical and histological outcomes in patients with chronic HCV infection have been discussed in this review. Finally, we focus on the effect of iron reduction on the rate of response to interferon antiviral therapy. Springer-Verlag 2008-05-08 2008-09 /pmc/articles/PMC2716881/ /pubmed/19669262 http://dx.doi.org/10.1007/s12072-008-9076-z Text en © The Author(s) 2008
spellingShingle Review Article
Franchini, Massimo
Targher, Giovanni
Capra, Franco
Montagnana, Martina
Lippi, Giuseppe
The effect of iron depletion on chronic hepatitis C virus infection
title The effect of iron depletion on chronic hepatitis C virus infection
title_full The effect of iron depletion on chronic hepatitis C virus infection
title_fullStr The effect of iron depletion on chronic hepatitis C virus infection
title_full_unstemmed The effect of iron depletion on chronic hepatitis C virus infection
title_short The effect of iron depletion on chronic hepatitis C virus infection
title_sort effect of iron depletion on chronic hepatitis c virus infection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716881/
https://www.ncbi.nlm.nih.gov/pubmed/19669262
http://dx.doi.org/10.1007/s12072-008-9076-z
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