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Exposure to Traffic Pollution and Increased Risk of Rheumatoid Arthritis
BACKGROUND: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease that affects approximately 1% of the adult population, and to date, genetic factors explain < 50% of the risk. Particulate air pollution, especially of traffic origin, has been linked to systemic inflammation in many...
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717131/ https://www.ncbi.nlm.nih.gov/pubmed/19654914 http://dx.doi.org/10.1289/ehp.0800503 |
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author | Hart, Jaime E. Laden, Francine Puett, Robin C. Costenbader, Karen H. Karlson, Elizabeth W. |
author_facet | Hart, Jaime E. Laden, Francine Puett, Robin C. Costenbader, Karen H. Karlson, Elizabeth W. |
author_sort | Hart, Jaime E. |
collection | PubMed |
description | BACKGROUND: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease that affects approximately 1% of the adult population, and to date, genetic factors explain < 50% of the risk. Particulate air pollution, especially of traffic origin, has been linked to systemic inflammation in many studies. OBJECTIVES: We examined the association of distance to road, a marker of traffic pollution exposure, and incidence of RA in a prospective cohort study. METHODS: We studied 90,297 U.S. women in the Nurses’ Health Study. We used a geographic information system to determine distance to road at the residence in 2000 as a measure of traffic exposure. Using Cox proportional hazard models, we examined the association of distance to road and incident RA (1976–2004) with adjustment for a large number of potential confounders. RESULTS: In models adjusted for age, calendar year, race, cigarette smoking, parity, lactation, menopausal status and hormone use, oral contraceptive use, body mass index, physical activity, and census-tract-level median income and house value, we observed an elevated risk of RA [hazard ratio (HR) = 1.31; 95% confidence interval (CI), 0.98–1.74] in women living within 50 m of a road, compared with those women living 200 m or farther away. We also observed this association in analyses among nonsmokers (HR = 1.62; 95% CI, 1.04–2.52), nonsmokers with rheumatoid factor (RF)-negative RA (HR = 1.77; 95% CI, 0.93–3.38), and nonsmokers with RF-positive RA (HR = 1.51; 95% CI, 0.82–2.77). We saw no elevations in risk in women living 50–200 m from the road. CONCLUSIONS: The observed association between exposure to traffic pollution and RA suggests that pollution from traffic in adulthood may be a newly identified environmental risk factor for RA. |
format | Text |
id | pubmed-2717131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-27171312009-08-04 Exposure to Traffic Pollution and Increased Risk of Rheumatoid Arthritis Hart, Jaime E. Laden, Francine Puett, Robin C. Costenbader, Karen H. Karlson, Elizabeth W. Environ Health Perspect Research BACKGROUND: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease that affects approximately 1% of the adult population, and to date, genetic factors explain < 50% of the risk. Particulate air pollution, especially of traffic origin, has been linked to systemic inflammation in many studies. OBJECTIVES: We examined the association of distance to road, a marker of traffic pollution exposure, and incidence of RA in a prospective cohort study. METHODS: We studied 90,297 U.S. women in the Nurses’ Health Study. We used a geographic information system to determine distance to road at the residence in 2000 as a measure of traffic exposure. Using Cox proportional hazard models, we examined the association of distance to road and incident RA (1976–2004) with adjustment for a large number of potential confounders. RESULTS: In models adjusted for age, calendar year, race, cigarette smoking, parity, lactation, menopausal status and hormone use, oral contraceptive use, body mass index, physical activity, and census-tract-level median income and house value, we observed an elevated risk of RA [hazard ratio (HR) = 1.31; 95% confidence interval (CI), 0.98–1.74] in women living within 50 m of a road, compared with those women living 200 m or farther away. We also observed this association in analyses among nonsmokers (HR = 1.62; 95% CI, 1.04–2.52), nonsmokers with rheumatoid factor (RF)-negative RA (HR = 1.77; 95% CI, 0.93–3.38), and nonsmokers with RF-positive RA (HR = 1.51; 95% CI, 0.82–2.77). We saw no elevations in risk in women living 50–200 m from the road. CONCLUSIONS: The observed association between exposure to traffic pollution and RA suggests that pollution from traffic in adulthood may be a newly identified environmental risk factor for RA. National Institute of Environmental Health Sciences 2009-07 2009-03-04 /pmc/articles/PMC2717131/ /pubmed/19654914 http://dx.doi.org/10.1289/ehp.0800503 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Hart, Jaime E. Laden, Francine Puett, Robin C. Costenbader, Karen H. Karlson, Elizabeth W. Exposure to Traffic Pollution and Increased Risk of Rheumatoid Arthritis |
title | Exposure to Traffic Pollution and Increased Risk of Rheumatoid Arthritis |
title_full | Exposure to Traffic Pollution and Increased Risk of Rheumatoid Arthritis |
title_fullStr | Exposure to Traffic Pollution and Increased Risk of Rheumatoid Arthritis |
title_full_unstemmed | Exposure to Traffic Pollution and Increased Risk of Rheumatoid Arthritis |
title_short | Exposure to Traffic Pollution and Increased Risk of Rheumatoid Arthritis |
title_sort | exposure to traffic pollution and increased risk of rheumatoid arthritis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717131/ https://www.ncbi.nlm.nih.gov/pubmed/19654914 http://dx.doi.org/10.1289/ehp.0800503 |
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