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Collagen-related biomarkers in severe sepsis: a big stretch?
Biomedical scientists are aggressively investigating biomarkers of disease and injury. The rationale for identifying biomarkers during pathological states, such as severe sepsis, is to improve clinical prognostication and stratify therapeutic interventions for optimal recovery. An added benefit of b...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717431/ https://www.ncbi.nlm.nih.gov/pubmed/19519949 http://dx.doi.org/10.1186/cc7879 |
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author | Morrison, Gavin Fraser, Douglas D |
author_facet | Morrison, Gavin Fraser, Douglas D |
author_sort | Morrison, Gavin |
collection | PubMed |
description | Biomedical scientists are aggressively investigating biomarkers of disease and injury. The rationale for identifying biomarkers during pathological states, such as severe sepsis, is to improve clinical prognostication and stratify therapeutic interventions for optimal recovery. An added benefit of biomarker studies is knowledge genesis on pathophysiological mechanisms, critical information that provides a basis for hypothesis-driven research. Unfortunately, biomarkers rarely alter our clinical approach in severe sepsis as they are often non-specific, lack adequate sensitivity and/or are difficult to measure and interpret accurately. Given the complexity and heterogeneity of severe sepsis, and the unique genetically derived susceptibilities of individuals, it is highly unlikely that one or even a handful of biomarkers will provide adequate biomedical information for clinical guidance. Thus, biomarkers will ultimately alter clinical decision making only once a panel of promising biomarkers is identified, maximizing sensitivity and specificity, and then adequately scrutinized with quantitative scoring methods over large populations of patients. |
format | Text |
id | pubmed-2717431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27174312010-06-02 Collagen-related biomarkers in severe sepsis: a big stretch? Morrison, Gavin Fraser, Douglas D Crit Care Commentary Biomedical scientists are aggressively investigating biomarkers of disease and injury. The rationale for identifying biomarkers during pathological states, such as severe sepsis, is to improve clinical prognostication and stratify therapeutic interventions for optimal recovery. An added benefit of biomarker studies is knowledge genesis on pathophysiological mechanisms, critical information that provides a basis for hypothesis-driven research. Unfortunately, biomarkers rarely alter our clinical approach in severe sepsis as they are often non-specific, lack adequate sensitivity and/or are difficult to measure and interpret accurately. Given the complexity and heterogeneity of severe sepsis, and the unique genetically derived susceptibilities of individuals, it is highly unlikely that one or even a handful of biomarkers will provide adequate biomedical information for clinical guidance. Thus, biomarkers will ultimately alter clinical decision making only once a panel of promising biomarkers is identified, maximizing sensitivity and specificity, and then adequately scrutinized with quantitative scoring methods over large populations of patients. BioMed Central 2009 2009-06-02 /pmc/articles/PMC2717431/ /pubmed/19519949 http://dx.doi.org/10.1186/cc7879 Text en Copyright © 2009 BioMed Central Ltd |
spellingShingle | Commentary Morrison, Gavin Fraser, Douglas D Collagen-related biomarkers in severe sepsis: a big stretch? |
title | Collagen-related biomarkers in severe sepsis: a big stretch? |
title_full | Collagen-related biomarkers in severe sepsis: a big stretch? |
title_fullStr | Collagen-related biomarkers in severe sepsis: a big stretch? |
title_full_unstemmed | Collagen-related biomarkers in severe sepsis: a big stretch? |
title_short | Collagen-related biomarkers in severe sepsis: a big stretch? |
title_sort | collagen-related biomarkers in severe sepsis: a big stretch? |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717431/ https://www.ncbi.nlm.nih.gov/pubmed/19519949 http://dx.doi.org/10.1186/cc7879 |
work_keys_str_mv | AT morrisongavin collagenrelatedbiomarkersinseveresepsisabigstretch AT fraserdouglasd collagenrelatedbiomarkersinseveresepsisabigstretch |