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Prevalence of hypospadias in Italy according to severity, gestational age and birthweight: an epidemiological study

BACKGROUND: Hypospadias is a congenital displacement of the urethral meatus in male newborns, being either an isolated defect at birth or a sign of sexual development disorders. The aim of this study was to assess the prevalence rate of hypospadias in different Districts of Italy, in order to make a...

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Autores principales: Ghirri, Paolo, Scaramuzzo, Rosa T, Bertelloni, Silvano, Pardi, Daniela, Celandroni, Amerigo, Cocchi, Guido, Danieli, Roberto, De Santis, Luisa, Di Stefano, Maria C, Gerola, Orietta, Giuffrè, Mario, Gragnani, Giuseppe S, Magnani, Cinzia, Meossi, Cristiano, Merusi, Ilaria, Sabatino, Giuseppe, Tumini, Stefano, Corsello, Giovanni, Boldrini, Antonio
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717564/
https://www.ncbi.nlm.nih.gov/pubmed/19558700
http://dx.doi.org/10.1186/1824-7288-35-18
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author Ghirri, Paolo
Scaramuzzo, Rosa T
Bertelloni, Silvano
Pardi, Daniela
Celandroni, Amerigo
Cocchi, Guido
Danieli, Roberto
De Santis, Luisa
Di Stefano, Maria C
Gerola, Orietta
Giuffrè, Mario
Gragnani, Giuseppe S
Magnani, Cinzia
Meossi, Cristiano
Merusi, Ilaria
Sabatino, Giuseppe
Tumini, Stefano
Corsello, Giovanni
Boldrini, Antonio
author_facet Ghirri, Paolo
Scaramuzzo, Rosa T
Bertelloni, Silvano
Pardi, Daniela
Celandroni, Amerigo
Cocchi, Guido
Danieli, Roberto
De Santis, Luisa
Di Stefano, Maria C
Gerola, Orietta
Giuffrè, Mario
Gragnani, Giuseppe S
Magnani, Cinzia
Meossi, Cristiano
Merusi, Ilaria
Sabatino, Giuseppe
Tumini, Stefano
Corsello, Giovanni
Boldrini, Antonio
author_sort Ghirri, Paolo
collection PubMed
description BACKGROUND: Hypospadias is a congenital displacement of the urethral meatus in male newborns, being either an isolated defect at birth or a sign of sexual development disorders. The aim of this study was to assess the prevalence rate of hypospadias in different Districts of Italy, in order to make a comparison with other countries all over the world. METHODS: We reviewed all the newborns file records (years 2001–2004) in 15 Italian Hospitals. RESULTS: We found an overall hypospadias prevalence rate of 3.066 ± 0.99 per 1000 live births (82.48% mild hypospadias, 17.52% moderate-severe). In newborns Small for Gestational Age (birthweight < 10(th )percentile) of any gestational age the prevalence rate of hypospadias was 6.25 per 1000 live births. Performing multivariate logistic regression analysis for different degrees of hypospadias according to severity, being born SGA remained the only risk factor for moderate-severe hypospadias (p = 0.00898) but not for mild forms (p > 0.1). CONCLUSION: In our sample the prevalence of hypospadias results as high as reported in previous European and American studies (3–4 per 1000 live births). Pathogenesis of isolated hypospadias is multifactorial (genetic, endocrine and environmental factors): however, the prevalence rate of hypospadias is higher in infants born small for gestational age than in newborns with normal birth weight.
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spelling pubmed-27175642009-07-29 Prevalence of hypospadias in Italy according to severity, gestational age and birthweight: an epidemiological study Ghirri, Paolo Scaramuzzo, Rosa T Bertelloni, Silvano Pardi, Daniela Celandroni, Amerigo Cocchi, Guido Danieli, Roberto De Santis, Luisa Di Stefano, Maria C Gerola, Orietta Giuffrè, Mario Gragnani, Giuseppe S Magnani, Cinzia Meossi, Cristiano Merusi, Ilaria Sabatino, Giuseppe Tumini, Stefano Corsello, Giovanni Boldrini, Antonio Ital J Pediatr Research BACKGROUND: Hypospadias is a congenital displacement of the urethral meatus in male newborns, being either an isolated defect at birth or a sign of sexual development disorders. The aim of this study was to assess the prevalence rate of hypospadias in different Districts of Italy, in order to make a comparison with other countries all over the world. METHODS: We reviewed all the newborns file records (years 2001–2004) in 15 Italian Hospitals. RESULTS: We found an overall hypospadias prevalence rate of 3.066 ± 0.99 per 1000 live births (82.48% mild hypospadias, 17.52% moderate-severe). In newborns Small for Gestational Age (birthweight < 10(th )percentile) of any gestational age the prevalence rate of hypospadias was 6.25 per 1000 live births. Performing multivariate logistic regression analysis for different degrees of hypospadias according to severity, being born SGA remained the only risk factor for moderate-severe hypospadias (p = 0.00898) but not for mild forms (p > 0.1). CONCLUSION: In our sample the prevalence of hypospadias results as high as reported in previous European and American studies (3–4 per 1000 live births). Pathogenesis of isolated hypospadias is multifactorial (genetic, endocrine and environmental factors): however, the prevalence rate of hypospadias is higher in infants born small for gestational age than in newborns with normal birth weight. BioMed Central 2009-06-27 /pmc/articles/PMC2717564/ /pubmed/19558700 http://dx.doi.org/10.1186/1824-7288-35-18 Text en Copyright © 2009 Ghirri et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Ghirri, Paolo
Scaramuzzo, Rosa T
Bertelloni, Silvano
Pardi, Daniela
Celandroni, Amerigo
Cocchi, Guido
Danieli, Roberto
De Santis, Luisa
Di Stefano, Maria C
Gerola, Orietta
Giuffrè, Mario
Gragnani, Giuseppe S
Magnani, Cinzia
Meossi, Cristiano
Merusi, Ilaria
Sabatino, Giuseppe
Tumini, Stefano
Corsello, Giovanni
Boldrini, Antonio
Prevalence of hypospadias in Italy according to severity, gestational age and birthweight: an epidemiological study
title Prevalence of hypospadias in Italy according to severity, gestational age and birthweight: an epidemiological study
title_full Prevalence of hypospadias in Italy according to severity, gestational age and birthweight: an epidemiological study
title_fullStr Prevalence of hypospadias in Italy according to severity, gestational age and birthweight: an epidemiological study
title_full_unstemmed Prevalence of hypospadias in Italy according to severity, gestational age and birthweight: an epidemiological study
title_short Prevalence of hypospadias in Italy according to severity, gestational age and birthweight: an epidemiological study
title_sort prevalence of hypospadias in italy according to severity, gestational age and birthweight: an epidemiological study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717564/
https://www.ncbi.nlm.nih.gov/pubmed/19558700
http://dx.doi.org/10.1186/1824-7288-35-18
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