Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases

Novel, comprehensive approaches for biomarker discovery and validation are urgently needed. One particular area of methodologic need is for discovery of novel genetic biomarkers in complex diseases and traits. Here, we review recent successes in the use of genome wide association (GWA) approaches to...

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Detalles Bibliográficos
Autores principales: Kingsmore, Stephen F., Lindquist, Ingrid E., Mudge, Joann, Beavis, William D.
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717811/
https://www.ncbi.nlm.nih.gov/pubmed/19662211
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author Kingsmore, Stephen F.
Lindquist, Ingrid E.
Mudge, Joann
Beavis, William D.
author_facet Kingsmore, Stephen F.
Lindquist, Ingrid E.
Mudge, Joann
Beavis, William D.
author_sort Kingsmore, Stephen F.
collection PubMed
description Novel, comprehensive approaches for biomarker discovery and validation are urgently needed. One particular area of methodologic need is for discovery of novel genetic biomarkers in complex diseases and traits. Here, we review recent successes in the use of genome wide association (GWA) approaches to identify genetic biomarkers in common human diseases and traits. Such studies are yielding initial insights into the allelic architecture of complex traits. In general, it appears that complex diseases are associated with many common polymorphisms, implying profound genetic heterogeneity between affected individuals.
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spelling pubmed-27178112009-08-06 Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases Kingsmore, Stephen F. Lindquist, Ingrid E. Mudge, Joann Beavis, William D. Biomark Insights Review Novel, comprehensive approaches for biomarker discovery and validation are urgently needed. One particular area of methodologic need is for discovery of novel genetic biomarkers in complex diseases and traits. Here, we review recent successes in the use of genome wide association (GWA) approaches to identify genetic biomarkers in common human diseases and traits. Such studies are yielding initial insights into the allelic architecture of complex traits. In general, it appears that complex diseases are associated with many common polymorphisms, implying profound genetic heterogeneity between affected individuals. Libertas Academica 2007-08-08 /pmc/articles/PMC2717811/ /pubmed/19662211 Text en © 2007 by the authors http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Kingsmore, Stephen F.
Lindquist, Ingrid E.
Mudge, Joann
Beavis, William D.
Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases
title Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases
title_full Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases
title_fullStr Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases
title_full_unstemmed Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases
title_short Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases
title_sort genome-wide association studies: progress in identifying genetic biomarkers in common, complex diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717811/
https://www.ncbi.nlm.nih.gov/pubmed/19662211
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