DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer

Free circulating DNA, which is thought to be derived from the primary tumour, can be detected in the blood of patients with cancer. Detection of genetic and epigenetic alteration in this tumour DNA offers a potential source of development of prognostic and predictive biomarkers for cancer. One such...

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Autores principales: Board, Ruth E, Knight, Lucy, Greystoke, Alastair, Blackhall, Fiona H, Hughes, Andrew, Dive, Caroline, Ranson, Malcolm
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717819/
https://www.ncbi.nlm.nih.gov/pubmed/19662228
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author Board, Ruth E
Knight, Lucy
Greystoke, Alastair
Blackhall, Fiona H
Hughes, Andrew
Dive, Caroline
Ranson, Malcolm
author_facet Board, Ruth E
Knight, Lucy
Greystoke, Alastair
Blackhall, Fiona H
Hughes, Andrew
Dive, Caroline
Ranson, Malcolm
author_sort Board, Ruth E
collection PubMed
description Free circulating DNA, which is thought to be derived from the primary tumour, can be detected in the blood of patients with cancer. Detection of genetic and epigenetic alteration in this tumour DNA offers a potential source of development of prognostic and predictive biomarkers for cancer. One such change is DNA methylation of the promotor region of tumour suppressor genes. This causes down regulation of tumour suppressor gene expression, a frequent event in carcinogenesis. Hypermethylation of the promotor region of a number of genes has been detected in many tumour types and more recently these changes have been detected in circulating tumour DNA. This review will summarise the literature detailing DNA methylation in circulating tumour DNA and discuss some of the current controversies and technical challenges facing its use as a potential biomarker for cancer.
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spelling pubmed-27178192009-08-06 DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer Board, Ruth E Knight, Lucy Greystoke, Alastair Blackhall, Fiona H Hughes, Andrew Dive, Caroline Ranson, Malcolm Biomark Insights Review Free circulating DNA, which is thought to be derived from the primary tumour, can be detected in the blood of patients with cancer. Detection of genetic and epigenetic alteration in this tumour DNA offers a potential source of development of prognostic and predictive biomarkers for cancer. One such change is DNA methylation of the promotor region of tumour suppressor genes. This causes down regulation of tumour suppressor gene expression, a frequent event in carcinogenesis. Hypermethylation of the promotor region of a number of genes has been detected in many tumour types and more recently these changes have been detected in circulating tumour DNA. This review will summarise the literature detailing DNA methylation in circulating tumour DNA and discuss some of the current controversies and technical challenges facing its use as a potential biomarker for cancer. Libertas Academica 2008-01-25 /pmc/articles/PMC2717819/ /pubmed/19662228 Text en © 2007 by the authors http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Board, Ruth E
Knight, Lucy
Greystoke, Alastair
Blackhall, Fiona H
Hughes, Andrew
Dive, Caroline
Ranson, Malcolm
DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer
title DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer
title_full DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer
title_fullStr DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer
title_full_unstemmed DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer
title_short DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer
title_sort dna methylation in circulating tumour dna as a biomarker for cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717819/
https://www.ncbi.nlm.nih.gov/pubmed/19662228
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