The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)

The extracellular matrix (ECM) plays a key role in the modulation of cancer cell invasion. In urothelial carcinoma of the bladder (UC) the role of ECM proteins has been widely studied. The mechanisms, which are involved in the development of invasion, progression and generalization, are complex, dep...

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Detalles Bibliográficos
Autores principales: Brunner, Andrea, Tzankov, Alexandar
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717820/
https://www.ncbi.nlm.nih.gov/pubmed/19662222
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author Brunner, Andrea
Tzankov, Alexandar
author_facet Brunner, Andrea
Tzankov, Alexandar
author_sort Brunner, Andrea
collection PubMed
description The extracellular matrix (ECM) plays a key role in the modulation of cancer cell invasion. In urothelial carcinoma of the bladder (UC) the role of ECM proteins has been widely studied. The mechanisms, which are involved in the development of invasion, progression and generalization, are complex, depending on the interaction of ECM proteins with each other as well as with cancer cells. The following review will focus on the pathogenetic role and prognostic value of structural proteins, such as laminins, collagens, fibronectin (FN), tenascin (Tn-C) and thrombospondin 1 (TSP1) in UC. In addition, the role of integrins mediating the interaction of ECM molecules and cancer cells will be addressed, since integrin-mediated FN, Tn-C and TSP1 interactions seem to play an important role during tumor cell invasion and angiogenesis.
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spelling pubmed-27178202009-08-06 The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review) Brunner, Andrea Tzankov, Alexandar Biomark Insights Review The extracellular matrix (ECM) plays a key role in the modulation of cancer cell invasion. In urothelial carcinoma of the bladder (UC) the role of ECM proteins has been widely studied. The mechanisms, which are involved in the development of invasion, progression and generalization, are complex, depending on the interaction of ECM proteins with each other as well as with cancer cells. The following review will focus on the pathogenetic role and prognostic value of structural proteins, such as laminins, collagens, fibronectin (FN), tenascin (Tn-C) and thrombospondin 1 (TSP1) in UC. In addition, the role of integrins mediating the interaction of ECM molecules and cancer cells will be addressed, since integrin-mediated FN, Tn-C and TSP1 interactions seem to play an important role during tumor cell invasion and angiogenesis. Libertas Academica 2007-11-05 /pmc/articles/PMC2717820/ /pubmed/19662222 Text en © 2007 by the authors http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Brunner, Andrea
Tzankov, Alexandar
The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)
title The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)
title_full The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)
title_fullStr The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)
title_full_unstemmed The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)
title_short The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)
title_sort role of structural extracellular matrix proteins in urothelial bladder cancer (review)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717820/
https://www.ncbi.nlm.nih.gov/pubmed/19662222
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