Increased Intrathecal Chemokine Receptor CCR2 Expression in Multiple Sclerosis

Expression of CCR2, CXCR3 and CCR4 on CD4(+) T or CD8(+) T cells in blood and cerebrospinal fluid (CSF) for multiple sclerosis (MS) was measured by 3-color flow cytometry, and compared to blood from healthy controls and CSF from patients with other inflammatory neurological diseases (INDs). CD4(+)CX...

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Detalles Bibliográficos
Autores principales: Nakajima, Hideto, Sugino, Masakazu, Kimura, Fumiharu, Hanafusa, Toshiaki, Ikemoto, Toshiyuki, Shimizu, Akira
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2007
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717838/
https://www.ncbi.nlm.nih.gov/pubmed/19662226
Descripción
Sumario:Expression of CCR2, CXCR3 and CCR4 on CD4(+) T or CD8(+) T cells in blood and cerebrospinal fluid (CSF) for multiple sclerosis (MS) was measured by 3-color flow cytometry, and compared to blood from healthy controls and CSF from patients with other inflammatory neurological diseases (INDs). CD4(+)CXCR3(+)/CD4(+)CCR4(+) ratio (representing Th1/Th2 balance) was higher in both CSF and blood of MS patients than those of IND patients or healthy controls. Percentage of CCR2-positive T cells was significantly higher in CSF from MS patients. Increased CCR2 expression on T cells in CSF and Th1/Th2 imbalance may reflect the pathological processes involved in MS.

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