A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth

BACKGROUND: Gastric cancer is the third most common malignancy affecting the general population worldwide. Aberrant activation of KRAS is a key factor in the development of many types of tumor, however, oncogenic mutations of KRAS are infrequent in gastric cancer. We have developed a novel quantitat...

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Detalles Bibliográficos
Autores principales: Mita, Hiroaki, Toyota, Minoru, Aoki, Fumio, Akashi, Hirofumi, Maruyama, Reo, Sasaki, Yasushi, Suzuki, Hiromu, Idogawa, Masashi, Kashima, Lisa, Yanagihara, Kazuyoshi, Fujita, Masahiro, Hosokawa, Masao, Kusano, Masanobu, Sabau, Sorin Vasile, Tatsumi, Haruyuki, Imai, Kohzoh, Shinomura, Yasuhisa, Tokino, Takashi
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717977/
https://www.ncbi.nlm.nih.gov/pubmed/19545448
http://dx.doi.org/10.1186/1471-2407-9-198

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