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Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and Snail1 induction – A model for cross-modulation

BACKGROUND: A feature of epithelial to mesenchymal transition (EMT) relevant to tumour dissemination is the reorganization of actin cytoskeleton/focal contacts, influencing cellular ECM adherence and motility. This is coupled with the transcriptional repression of E-cadherin, often mediated by Snail...

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Detalles Bibliográficos
Autores principales:	Hugo, Honor J, Wafai, Razan, Blick, Tony, Thompson, Erik W, Newgreen, Donald F
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717979/ https://www.ncbi.nlm.nih.gov/pubmed/19604397 http://dx.doi.org/10.1186/1471-2407-9-235

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