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Usefulness of Single Voxel Proton MR Spectroscopy in the Evaluation of Hippocampal Sclerosis

OBJECTIVE: The purpose of our study was to determine the ability of H-1 MR spectroscopy (MRS) to lateralize the lesion in patients with hippocampal sclerosis. MATERIALS AND METHODS: Twenty healthy volunteers and 25 patients with intractable temporal lobe epilepsy whose MR imaging diagnosis was unila...

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Autores principales: Chang, Kee-Hyun, Kim, Hong Dae, Park, Sun-Won, Song, In Chan, Yu, In Kyu, Han, Moon Hee, Lee, Sang Kun, Chung, Chun-Kee, Park, Yang Hee
Formato: Texto
Lenguaje:English
Publicado: The Korean Radiological Society 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718133/
https://www.ncbi.nlm.nih.gov/pubmed/11752925
http://dx.doi.org/10.3348/kjr.2000.1.1.25
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author Chang, Kee-Hyun
Kim, Hong Dae
Park, Sun-Won
Song, In Chan
Yu, In Kyu
Han, Moon Hee
Lee, Sang Kun
Chung, Chun-Kee
Park, Yang Hee
author_facet Chang, Kee-Hyun
Kim, Hong Dae
Park, Sun-Won
Song, In Chan
Yu, In Kyu
Han, Moon Hee
Lee, Sang Kun
Chung, Chun-Kee
Park, Yang Hee
author_sort Chang, Kee-Hyun
collection PubMed
description OBJECTIVE: The purpose of our study was to determine the ability of H-1 MR spectroscopy (MRS) to lateralize the lesion in patients with hippocampal sclerosis. MATERIALS AND METHODS: Twenty healthy volunteers and 25 patients with intractable temporal lobe epilepsy whose MR imaging diagnosis was unilateral hippocampal sclerosis were included. This diagnosis was based on the presence of unilateral atrophy and/or high T2 signal intensity of the hippocampus. Single-voxel H-1 MRS was carried out on a 1.5-T unit using PRESS sequence (TE, 136 msec). Spectra were obtained from hippocampal areas bilaterally with volumes of interest (VOIs) of 6.0 cm(3) and 2.25 cm(3) in healthy volunteers, and of either 6.0 cm(3) (n = 14) or 2.25 cm(3) (n = 11) in patients. Metabolite ratios of NAA/Cho and NAA/Cr were calculated from relative peak height measurements. The capability of MRS to lateralize the lesion and to detect bilateral abnormalities was compared with MR imaging diagnosis as a standard of reference. RESULTS: In healthy volunteers, NAA/Cho and NAA/Cr ratios were greater than 0.8 and 1.0, respectively. In patients, the mean values of these ratios were significantly lower on the lesion side than on the contralateral side, and lower than those of healthy volunteers (p < .05). The overall correct lateralization rate of MRS was 72% (18/25); this rate was lower with a VOI of 6.0 cm(3) than of 2.25 cm(3) (64% versus 82%, p < .05). Bilateral abnormalities on MRS were found in 24% (6/25) of cases. CONCLUSION: Although its rate of correct lateralization is low, single-voxel H-1 MRS is a useful and promising diagnostic tool in the evaluation of hippocampal sclerosis, particularly for the detection of bilateral abnormalities. To improve the diagnostic accuracy of H-1 MRS, further investigation, including the use of a smaller VOI and measurement of the absolute amount of metabolites, are needed.
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spelling pubmed-27181332009-07-30 Usefulness of Single Voxel Proton MR Spectroscopy in the Evaluation of Hippocampal Sclerosis Chang, Kee-Hyun Kim, Hong Dae Park, Sun-Won Song, In Chan Yu, In Kyu Han, Moon Hee Lee, Sang Kun Chung, Chun-Kee Park, Yang Hee Korean J Radiol Original Article OBJECTIVE: The purpose of our study was to determine the ability of H-1 MR spectroscopy (MRS) to lateralize the lesion in patients with hippocampal sclerosis. MATERIALS AND METHODS: Twenty healthy volunteers and 25 patients with intractable temporal lobe epilepsy whose MR imaging diagnosis was unilateral hippocampal sclerosis were included. This diagnosis was based on the presence of unilateral atrophy and/or high T2 signal intensity of the hippocampus. Single-voxel H-1 MRS was carried out on a 1.5-T unit using PRESS sequence (TE, 136 msec). Spectra were obtained from hippocampal areas bilaterally with volumes of interest (VOIs) of 6.0 cm(3) and 2.25 cm(3) in healthy volunteers, and of either 6.0 cm(3) (n = 14) or 2.25 cm(3) (n = 11) in patients. Metabolite ratios of NAA/Cho and NAA/Cr were calculated from relative peak height measurements. The capability of MRS to lateralize the lesion and to detect bilateral abnormalities was compared with MR imaging diagnosis as a standard of reference. RESULTS: In healthy volunteers, NAA/Cho and NAA/Cr ratios were greater than 0.8 and 1.0, respectively. In patients, the mean values of these ratios were significantly lower on the lesion side than on the contralateral side, and lower than those of healthy volunteers (p < .05). The overall correct lateralization rate of MRS was 72% (18/25); this rate was lower with a VOI of 6.0 cm(3) than of 2.25 cm(3) (64% versus 82%, p < .05). Bilateral abnormalities on MRS were found in 24% (6/25) of cases. CONCLUSION: Although its rate of correct lateralization is low, single-voxel H-1 MRS is a useful and promising diagnostic tool in the evaluation of hippocampal sclerosis, particularly for the detection of bilateral abnormalities. To improve the diagnostic accuracy of H-1 MRS, further investigation, including the use of a smaller VOI and measurement of the absolute amount of metabolites, are needed. The Korean Radiological Society 2000 2000-03-31 /pmc/articles/PMC2718133/ /pubmed/11752925 http://dx.doi.org/10.3348/kjr.2000.1.1.25 Text en Copyright © 2000 The Korean Radiological Society http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chang, Kee-Hyun
Kim, Hong Dae
Park, Sun-Won
Song, In Chan
Yu, In Kyu
Han, Moon Hee
Lee, Sang Kun
Chung, Chun-Kee
Park, Yang Hee
Usefulness of Single Voxel Proton MR Spectroscopy in the Evaluation of Hippocampal Sclerosis
title Usefulness of Single Voxel Proton MR Spectroscopy in the Evaluation of Hippocampal Sclerosis
title_full Usefulness of Single Voxel Proton MR Spectroscopy in the Evaluation of Hippocampal Sclerosis
title_fullStr Usefulness of Single Voxel Proton MR Spectroscopy in the Evaluation of Hippocampal Sclerosis
title_full_unstemmed Usefulness of Single Voxel Proton MR Spectroscopy in the Evaluation of Hippocampal Sclerosis
title_short Usefulness of Single Voxel Proton MR Spectroscopy in the Evaluation of Hippocampal Sclerosis
title_sort usefulness of single voxel proton mr spectroscopy in the evaluation of hippocampal sclerosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718133/
https://www.ncbi.nlm.nih.gov/pubmed/11752925
http://dx.doi.org/10.3348/kjr.2000.1.1.25
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