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Primary Antiphospholipid Antibody Syndrome: Neuroradiologic Findings in 11 Patients
OBJECTIVE: To describe the neuroradiologic findings of primary antiphospholipid antibody syndrome (PAPS). MATERIALS AND METHODS: During a recent two-year period, abnormally elevated antiphospholipid antibodies were detected in a total of 751 patients. In any cases in which risk factors for stroke we...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Radiological Society
2000
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718138/ https://www.ncbi.nlm.nih.gov/pubmed/11752922 http://dx.doi.org/10.3348/kjr.2000.1.1.5 |
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author | Kim, Jung Hoon Choi, Choong-Gon Choi, Soo-Jung Lee, Ho Kyu Suh, Dae Chul |
author_facet | Kim, Jung Hoon Choi, Choong-Gon Choi, Soo-Jung Lee, Ho Kyu Suh, Dae Chul |
author_sort | Kim, Jung Hoon |
collection | PubMed |
description | OBJECTIVE: To describe the neuroradiologic findings of primary antiphospholipid antibody syndrome (PAPS). MATERIALS AND METHODS: During a recent two-year period, abnormally elevated antiphospholipid antibodies were detected in a total of 751 patients. In any cases in which risk factors for stroke were detected - hypertension, diabetes mellitus, hyperlipidemia, smoking, and the presence of SLE or other connective tissue diseases - PAPS was not diagnosed. Neuroradiologic studies were performed in 11 of 32 patients with PAPS. We retrospectively reviewed brain CT (n = 7), MR (n = 8), and cerebral angiography (n = 8) in 11 patients with special attention to the presence of brain parenchymal lesions and cerebral arterial or venous abnormalities. RESULTS: CT or MR findings of PAPS included nonspecific multiple hyper-intensity foci in deep white matter on T2-weighted images (5/11), a large infarct in the territory of the middle cerebral artery (4/11), diffuse cortical atrophy (2/11), focal hemorrhage (2/11), and dural sinus thrombosis (1/11). Angiographic findings were normal (5/8) or reflected either occlusion of a large cerebral artery (2/8) or dural sinus thrombosis (1/8). CONCLUSION: Neuroradiologic findings of PAPS are nonspecific but in young or middle-aged adults who show the above mentioned CT or MR findings, and in whom risk factors for stroke are not present, the condition should be suspected. |
format | Text |
id | pubmed-2718138 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | The Korean Radiological Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-27181382009-07-30 Primary Antiphospholipid Antibody Syndrome: Neuroradiologic Findings in 11 Patients Kim, Jung Hoon Choi, Choong-Gon Choi, Soo-Jung Lee, Ho Kyu Suh, Dae Chul Korean J Radiol Original Article OBJECTIVE: To describe the neuroradiologic findings of primary antiphospholipid antibody syndrome (PAPS). MATERIALS AND METHODS: During a recent two-year period, abnormally elevated antiphospholipid antibodies were detected in a total of 751 patients. In any cases in which risk factors for stroke were detected - hypertension, diabetes mellitus, hyperlipidemia, smoking, and the presence of SLE or other connective tissue diseases - PAPS was not diagnosed. Neuroradiologic studies were performed in 11 of 32 patients with PAPS. We retrospectively reviewed brain CT (n = 7), MR (n = 8), and cerebral angiography (n = 8) in 11 patients with special attention to the presence of brain parenchymal lesions and cerebral arterial or venous abnormalities. RESULTS: CT or MR findings of PAPS included nonspecific multiple hyper-intensity foci in deep white matter on T2-weighted images (5/11), a large infarct in the territory of the middle cerebral artery (4/11), diffuse cortical atrophy (2/11), focal hemorrhage (2/11), and dural sinus thrombosis (1/11). Angiographic findings were normal (5/8) or reflected either occlusion of a large cerebral artery (2/8) or dural sinus thrombosis (1/8). CONCLUSION: Neuroradiologic findings of PAPS are nonspecific but in young or middle-aged adults who show the above mentioned CT or MR findings, and in whom risk factors for stroke are not present, the condition should be suspected. The Korean Radiological Society 2000 2000-03-31 /pmc/articles/PMC2718138/ /pubmed/11752922 http://dx.doi.org/10.3348/kjr.2000.1.1.5 Text en Copyright © 2000 The Korean Radiological Society http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Jung Hoon Choi, Choong-Gon Choi, Soo-Jung Lee, Ho Kyu Suh, Dae Chul Primary Antiphospholipid Antibody Syndrome: Neuroradiologic Findings in 11 Patients |
title | Primary Antiphospholipid Antibody Syndrome: Neuroradiologic Findings in 11 Patients |
title_full | Primary Antiphospholipid Antibody Syndrome: Neuroradiologic Findings in 11 Patients |
title_fullStr | Primary Antiphospholipid Antibody Syndrome: Neuroradiologic Findings in 11 Patients |
title_full_unstemmed | Primary Antiphospholipid Antibody Syndrome: Neuroradiologic Findings in 11 Patients |
title_short | Primary Antiphospholipid Antibody Syndrome: Neuroradiologic Findings in 11 Patients |
title_sort | primary antiphospholipid antibody syndrome: neuroradiologic findings in 11 patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718138/ https://www.ncbi.nlm.nih.gov/pubmed/11752922 http://dx.doi.org/10.3348/kjr.2000.1.1.5 |
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