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Airway Reactivity to Bronchoconstrictor and Bronchodilator: Assessment Using Thin-Section and Volumetric Three-Dimensional CT
OBJECTIVE: To determine the extent to which thin-section and volumetric three-dimensional CT can depict airway reactivity to bronchostimulator, and to assess the effect of different airway sizes on the degree of reactivity. MATERIALS AND METHODS: In eight dogs, thin-section CT scans were obtained be...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Radiological Society
2000
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718181/ https://www.ncbi.nlm.nih.gov/pubmed/11752943 http://dx.doi.org/10.3348/kjr.2000.1.3.127 |
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author | Han, Boo-Kyung Im, Jung-Gi Kim, Hak Soo Koo, Jin Mo Kim, Hong Dae Yeon, Kyung Mo |
author_facet | Han, Boo-Kyung Im, Jung-Gi Kim, Hak Soo Koo, Jin Mo Kim, Hong Dae Yeon, Kyung Mo |
author_sort | Han, Boo-Kyung |
collection | PubMed |
description | OBJECTIVE: To determine the extent to which thin-section and volumetric three-dimensional CT can depict airway reactivity to bronchostimulator, and to assess the effect of different airway sizes on the degree of reactivity. MATERIALS AND METHODS: In eight dogs, thin-section CT scans were obtained before and after the administration of methacholine and ventolin. Cross-sectional areas of bronchi at multiple levels, as shown by axial CT, proximal airway volume as revealed by three-dimensional imaging, and peak airway pressure were measured. The significance of airway change induced by methacholine and ventolin, expressed by percentage changes in cross-sectional area, proximal airway volume, and peak airway pressure was statistically evaluated, as was correlation between the degree of airway reactivity and the area of airways. RESULTS: Cross-sectional areas of the bronchi decreased significantly after the administration of methacholine, and scans obtained after a delay of 5 minutes showed that normalization was insufficient. Ventolin induced a significant increase in cross-sectional areas and an increase in proximal airway volume, while the effect of methacholine on the latter was the opposite. Peak airway pressure increased after the administration of methacholine, and after a 5-minute delay its level was near that of the control state. Ventolin, however, induced no significant decrease. The degree of airway reactivity did not correlate with airway size. CONCLUSION: Thin-section and volumetric spiral CT with three-dimensional reconstruction can demonstrate airway reactivity to bronchostimulator. The degree of reactivity did not correlate with airway size. |
format | Text |
id | pubmed-2718181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | The Korean Radiological Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-27181812009-07-30 Airway Reactivity to Bronchoconstrictor and Bronchodilator: Assessment Using Thin-Section and Volumetric Three-Dimensional CT Han, Boo-Kyung Im, Jung-Gi Kim, Hak Soo Koo, Jin Mo Kim, Hong Dae Yeon, Kyung Mo Korean J Radiol Original Article OBJECTIVE: To determine the extent to which thin-section and volumetric three-dimensional CT can depict airway reactivity to bronchostimulator, and to assess the effect of different airway sizes on the degree of reactivity. MATERIALS AND METHODS: In eight dogs, thin-section CT scans were obtained before and after the administration of methacholine and ventolin. Cross-sectional areas of bronchi at multiple levels, as shown by axial CT, proximal airway volume as revealed by three-dimensional imaging, and peak airway pressure were measured. The significance of airway change induced by methacholine and ventolin, expressed by percentage changes in cross-sectional area, proximal airway volume, and peak airway pressure was statistically evaluated, as was correlation between the degree of airway reactivity and the area of airways. RESULTS: Cross-sectional areas of the bronchi decreased significantly after the administration of methacholine, and scans obtained after a delay of 5 minutes showed that normalization was insufficient. Ventolin induced a significant increase in cross-sectional areas and an increase in proximal airway volume, while the effect of methacholine on the latter was the opposite. Peak airway pressure increased after the administration of methacholine, and after a 5-minute delay its level was near that of the control state. Ventolin, however, induced no significant decrease. The degree of airway reactivity did not correlate with airway size. CONCLUSION: Thin-section and volumetric spiral CT with three-dimensional reconstruction can demonstrate airway reactivity to bronchostimulator. The degree of reactivity did not correlate with airway size. The Korean Radiological Society 2000 2000-09-30 /pmc/articles/PMC2718181/ /pubmed/11752943 http://dx.doi.org/10.3348/kjr.2000.1.3.127 Text en Copyright © 2000 The Korean Radiological Society http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Han, Boo-Kyung Im, Jung-Gi Kim, Hak Soo Koo, Jin Mo Kim, Hong Dae Yeon, Kyung Mo Airway Reactivity to Bronchoconstrictor and Bronchodilator: Assessment Using Thin-Section and Volumetric Three-Dimensional CT |
title | Airway Reactivity to Bronchoconstrictor and Bronchodilator: Assessment Using Thin-Section and Volumetric Three-Dimensional CT |
title_full | Airway Reactivity to Bronchoconstrictor and Bronchodilator: Assessment Using Thin-Section and Volumetric Three-Dimensional CT |
title_fullStr | Airway Reactivity to Bronchoconstrictor and Bronchodilator: Assessment Using Thin-Section and Volumetric Three-Dimensional CT |
title_full_unstemmed | Airway Reactivity to Bronchoconstrictor and Bronchodilator: Assessment Using Thin-Section and Volumetric Three-Dimensional CT |
title_short | Airway Reactivity to Bronchoconstrictor and Bronchodilator: Assessment Using Thin-Section and Volumetric Three-Dimensional CT |
title_sort | airway reactivity to bronchoconstrictor and bronchodilator: assessment using thin-section and volumetric three-dimensional ct |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718181/ https://www.ncbi.nlm.nih.gov/pubmed/11752943 http://dx.doi.org/10.3348/kjr.2000.1.3.127 |
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