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APOBEC3G-Depleted Resting CD4(+) T Cells Remain Refractory to HIV1 Infection
BACKGROUND: CD4+ T lymphocytes are the primary targets of HIV1 but cannot be infected when fully quiescent, due to a post-entry block preventing the completion of reverse transcription. Chiu et al. recently proposed that this restriction reflects the action of APOBEC3G (A3G). They further suggested...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719058/ https://www.ncbi.nlm.nih.gov/pubmed/19668336 http://dx.doi.org/10.1371/journal.pone.0006571 |