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A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease

BACKGROUND: In preclinical models, antagonism of metabotropic glutamate receptor 5 (mGluR5) reduces transient lower oesophageal sphincter relaxations (TLOSRs) and increases LOS pressure. This study evaluated the effect of ADX10059, a potent, selective, negative allosteric modulator of mGluR5, on oes...

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Detalles Bibliográficos
Autores principales:	Keywood, C, Wakefield, M, Tack, J
Formato:	Texto
Lenguaje:	English
Publicado:	BMJ Group 2009
Materias:	Oesophagus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719084/ https://www.ncbi.nlm.nih.gov/pubmed/19460767 http://dx.doi.org/10.1136/gut.2008.162040

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