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Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy
Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder characterized by a nonneoplastic proliferation of distinctive histiocyte cells within lymph node sinuses and lymphatics in extranodal sites. SHML occurs worldwide and is primarily a disease of childhood and early adulthood. A...
Autores principales: | , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Academy of Medical Sciences
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719199/ https://www.ncbi.nlm.nih.gov/pubmed/19654967 http://dx.doi.org/10.3346/jkms.2009.24.4.760 |
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author | Ju, Jinyung Kwon, Yong Soo Jo, Kae Jung Chae, Dong Ryeol Lim, Jung Hwan Ban, Hee Jung Chi, Su Young Oh, In Jae Kim, Ku Sik Kim, Yu Il Kim, Young Chul Lim, Sung Chul |
author_facet | Ju, Jinyung Kwon, Yong Soo Jo, Kae Jung Chae, Dong Ryeol Lim, Jung Hwan Ban, Hee Jung Chi, Su Young Oh, In Jae Kim, Ku Sik Kim, Yu Il Kim, Young Chul Lim, Sung Chul |
author_sort | Ju, Jinyung |
collection | PubMed |
description | Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder characterized by a nonneoplastic proliferation of distinctive histiocyte cells within lymph node sinuses and lymphatics in extranodal sites. SHML occurs worldwide and is primarily a disease of childhood and early adulthood. A 26-yr-old man presented with painless palpable lymph node in cervical area. Radiographic studies revealed pleural effusion with lymphadenopathy and calcification in mediastinum. The cervical lymph node biopsy showed dilated sinuses filled with histiocytes with clear cytoplasm. The cells stained positive with CD68 and S-100. These cytologic and immunohistochemical findings were considered consistent with the diagnosis of SHML. |
format | Text |
id | pubmed-2719199 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-27191992009-08-04 Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy Ju, Jinyung Kwon, Yong Soo Jo, Kae Jung Chae, Dong Ryeol Lim, Jung Hwan Ban, Hee Jung Chi, Su Young Oh, In Jae Kim, Ku Sik Kim, Yu Il Kim, Young Chul Lim, Sung Chul J Korean Med Sci Case Report Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder characterized by a nonneoplastic proliferation of distinctive histiocyte cells within lymph node sinuses and lymphatics in extranodal sites. SHML occurs worldwide and is primarily a disease of childhood and early adulthood. A 26-yr-old man presented with painless palpable lymph node in cervical area. Radiographic studies revealed pleural effusion with lymphadenopathy and calcification in mediastinum. The cervical lymph node biopsy showed dilated sinuses filled with histiocytes with clear cytoplasm. The cells stained positive with CD68 and S-100. These cytologic and immunohistochemical findings were considered consistent with the diagnosis of SHML. The Korean Academy of Medical Sciences 2009-08 2009-07-30 /pmc/articles/PMC2719199/ /pubmed/19654967 http://dx.doi.org/10.3346/jkms.2009.24.4.760 Text en Copyright © 2009 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Ju, Jinyung Kwon, Yong Soo Jo, Kae Jung Chae, Dong Ryeol Lim, Jung Hwan Ban, Hee Jung Chi, Su Young Oh, In Jae Kim, Ku Sik Kim, Yu Il Kim, Young Chul Lim, Sung Chul Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy |
title | Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy |
title_full | Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy |
title_fullStr | Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy |
title_full_unstemmed | Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy |
title_short | Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy |
title_sort | sinus histiocytosis with massive lymphadenopathy: a case report with pleural effusion and cervical lymphadenopathy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719199/ https://www.ncbi.nlm.nih.gov/pubmed/19654967 http://dx.doi.org/10.3346/jkms.2009.24.4.760 |
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