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Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy

Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder characterized by a nonneoplastic proliferation of distinctive histiocyte cells within lymph node sinuses and lymphatics in extranodal sites. SHML occurs worldwide and is primarily a disease of childhood and early adulthood. A...

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Autores principales: Ju, Jinyung, Kwon, Yong Soo, Jo, Kae Jung, Chae, Dong Ryeol, Lim, Jung Hwan, Ban, Hee Jung, Chi, Su Young, Oh, In Jae, Kim, Ku Sik, Kim, Yu Il, Kim, Young Chul, Lim, Sung Chul
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719199/
https://www.ncbi.nlm.nih.gov/pubmed/19654967
http://dx.doi.org/10.3346/jkms.2009.24.4.760
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author Ju, Jinyung
Kwon, Yong Soo
Jo, Kae Jung
Chae, Dong Ryeol
Lim, Jung Hwan
Ban, Hee Jung
Chi, Su Young
Oh, In Jae
Kim, Ku Sik
Kim, Yu Il
Kim, Young Chul
Lim, Sung Chul
author_facet Ju, Jinyung
Kwon, Yong Soo
Jo, Kae Jung
Chae, Dong Ryeol
Lim, Jung Hwan
Ban, Hee Jung
Chi, Su Young
Oh, In Jae
Kim, Ku Sik
Kim, Yu Il
Kim, Young Chul
Lim, Sung Chul
author_sort Ju, Jinyung
collection PubMed
description Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder characterized by a nonneoplastic proliferation of distinctive histiocyte cells within lymph node sinuses and lymphatics in extranodal sites. SHML occurs worldwide and is primarily a disease of childhood and early adulthood. A 26-yr-old man presented with painless palpable lymph node in cervical area. Radiographic studies revealed pleural effusion with lymphadenopathy and calcification in mediastinum. The cervical lymph node biopsy showed dilated sinuses filled with histiocytes with clear cytoplasm. The cells stained positive with CD68 and S-100. These cytologic and immunohistochemical findings were considered consistent with the diagnosis of SHML.
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spelling pubmed-27191992009-08-04 Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy Ju, Jinyung Kwon, Yong Soo Jo, Kae Jung Chae, Dong Ryeol Lim, Jung Hwan Ban, Hee Jung Chi, Su Young Oh, In Jae Kim, Ku Sik Kim, Yu Il Kim, Young Chul Lim, Sung Chul J Korean Med Sci Case Report Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder characterized by a nonneoplastic proliferation of distinctive histiocyte cells within lymph node sinuses and lymphatics in extranodal sites. SHML occurs worldwide and is primarily a disease of childhood and early adulthood. A 26-yr-old man presented with painless palpable lymph node in cervical area. Radiographic studies revealed pleural effusion with lymphadenopathy and calcification in mediastinum. The cervical lymph node biopsy showed dilated sinuses filled with histiocytes with clear cytoplasm. The cells stained positive with CD68 and S-100. These cytologic and immunohistochemical findings were considered consistent with the diagnosis of SHML. The Korean Academy of Medical Sciences 2009-08 2009-07-30 /pmc/articles/PMC2719199/ /pubmed/19654967 http://dx.doi.org/10.3346/jkms.2009.24.4.760 Text en Copyright © 2009 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ju, Jinyung
Kwon, Yong Soo
Jo, Kae Jung
Chae, Dong Ryeol
Lim, Jung Hwan
Ban, Hee Jung
Chi, Su Young
Oh, In Jae
Kim, Ku Sik
Kim, Yu Il
Kim, Young Chul
Lim, Sung Chul
Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy
title Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy
title_full Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy
title_fullStr Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy
title_full_unstemmed Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy
title_short Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy
title_sort sinus histiocytosis with massive lymphadenopathy: a case report with pleural effusion and cervical lymphadenopathy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719199/
https://www.ncbi.nlm.nih.gov/pubmed/19654967
http://dx.doi.org/10.3346/jkms.2009.24.4.760
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