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Kinome Sirna Screen Identifies SMG-1 as a Negative Regulator of Hypoxia-inducible Factor-1α in Hypoxia

Hypoxia-inducible factor-1 (HIF-1) plays a central role in tumor progression by regulating genes involved in proliferation, glycolysis, angiogenesis, and metastasis. To improve our understanding of HIF-1 regulation by kinome, we screened a kinase-specific small interference RNA library using a hypox...

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Detalles Bibliográficos
Autores principales:	Chen, Run-Qiang, Yang, Qing-Kai, Chen, Yan-Ling, Oliveira, Vasco A., Dalton, William S., Fearns, Colleen, Lee, Jiing-Dwan
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Molecular Basis of Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719310/ https://www.ncbi.nlm.nih.gov/pubmed/19406746 http://dx.doi.org/10.1074/jbc.M109.014316

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