Cargando…

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

Hypoxia-inducible factor (HIF) controls an extensive range of adaptive responses to hypoxia. To better understand this transcriptional cascade we performed genome-wide chromatin immunoprecipitation using antibodies to two major HIF-α subunits, and correlated the results with genome-wide transcript p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mole, David R., Blancher, Christine, Copley, Richard R., Pollard, Patrick J., Gleadle, Jonathan M., Ragoussis, Jiannis, Ratcliffe, Peter J.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Transcription, Chromatin, and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719312/ https://www.ncbi.nlm.nih.gov/pubmed/19386601 http://dx.doi.org/10.1074/jbc.M901790200

Ejemplares similares

Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
por: Bao, Lei, et al.
Publicado: (2018)

Cyclical Chromatin Looping and Transcription Factor Association on the Regulatory Regions of the p21 (CDKN1A) Gene in Response to 1α,25-Dihydroxyvitamin D(3)
por: Saramäki, Anna, et al.
Publicado: (2009)

Requirements for Two Proximal NF-κB Binding Sites and IκB-ζ in IL-17A-induced Human β-Defensin 2 Expression by Conducting Airway Epithelium
por: Kao, Cheng-Yuan, et al.
Publicado: (2008)

CCCTC-binding Factor Activates PARP-1 Affecting DNA Methylation Machinery
por: Guastafierro, Tiziana, et al.
Publicado: (2008)

Closed Chromatin Architecture Is Induced by an RNA Duplex Targeting the HIV-1 Promoter Region
por: Suzuki, Kazuo, et al.
Publicado: (2008)

Multimerization and H3K9me3 Binding Are Required for CDYL1b Heterochromatin Association
por: Franz, Henriette, et al.
Publicado: (2009)

Antagonistic Roles for BRM and BRG1 SWI/SNF Complexes in Differentiation
por: Flowers, Stephen, et al.
Publicado: (2009)

Interaction between the Transactivation Domain of p53 and PC4 Exemplifies Acidic Activation Domains as Single-stranded DNA Mimics
por: Rajagopalan, Sridharan, et al.
Publicado: (2009)

Identification of Caspase-mediated Decay of Interferon Regulatory Factor-3, Exploited by a Kaposi Sarcoma-associated Herpesvirus Immunoregulatory Protein
por: Aresté, Cristina, et al.
Publicado: (2009)

Silencing of the Transforming Growth Factor-β (TGFβ) Receptor II by Krüppel-like Factor 14 Underscores the Importance of a Negative Feedback Mechanism in TGFβ Signaling
por: Truty, Mark J., et al.
Publicado: (2009)

The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate
por: Li, Yan, et al.
Publicado: (2009)

Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity
por: Wang, Jing, et al.
Publicado: (2017)

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia
por: Benita, Yair, et al.
Publicado: (2009)

Enhancer of Zeste Homologue 2 (EZH2) Down-regulates RUNX3 by Increasing Histone H3 Methylation
por: Fujii, Satoshi, et al.
Publicado: (2008)

Activation of p300 Histone Acetyltransferase Activity Is an Early Endothelial Response to Laminar Shear Stress and Is Essential for Stimulation of Endothelial Nitric-oxide Synthase mRNA Transcription
por: Chen, Wei, et al.
Publicado: (2008)

MafA and MafB Regulate Pdx1 Transcription through the Area II Control Region in Pancreatic β Cells
por: Vanhoose, Amanda M., et al.
Publicado: (2008)

Placenta-specific Methylation of the Vitamin D 24-Hydroxylase Gene: IMPLICATIONS FOR FEEDBACK AUTOREGULATION OF ACTIVE VITAMIN D LEVELS AT THE FETOMATERNAL INTERFACE
por: Novakovic, Boris, et al.
Publicado: (2009)

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins
por: Trojer, Patrick, et al.
Publicado: (2009)

Direct Inhibition of RNA Polymerase II Transcription by RECQL5
por: Aygün, Ozan, et al.
Publicado: (2009)

Heterogeneous Nuclear Ribonucleoprotein L Is a Subunit of Human KMT3a/Set2 Complex Required for H3 Lys-36 Trimethylation Activity in Vivo
por: Yuan, Wen, et al.
Publicado: (2009)

Transcriptional Activation by MEIS1A in Response to Protein Kinase A Signaling Requires the Transducers of Regulated CREB Family of CREB Co-activators
por: Goh, Siew-Lee, et al.
Publicado: (2009)

Translational Isoforms of FOG1 Regulate GATA1-interacting Complexes
por: Snow, Jonathan W., et al.
Publicado: (2009)

Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2
por: Choudhry, Hani, et al.
Publicado: (2014)

Destruction of a distal hypoxia response element abolishes trans-activation of the PAG1 gene mediated by HIF-independent chromatin looping
por: Schörg, Alexandra, et al.
Publicado: (2015)

PERK/eIF2α signaling inhibits HIF-induced gene expression during the unfolded protein response via YB1-dependent regulation of HIF1α translation
por: Ivanova, Iglika G, et al.
Publicado: (2018)

XIAP upregulates expression of HIF target genes by targeting HIF1α for Lys(63)-linked polyubiquitination
por: Park, Catherine V., et al.
Publicado: (2017)

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival
por: Choudhry, H, et al.
Publicado: (2015)

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
por: Chan, Mun Chiang, et al.
Publicado: (2016)

Erratum: Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival
por: Choudhry, H, et al.
Publicado: (2015)

Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin
por: Smythies, James A, et al.
Publicado: (2018)

Hypoxia-inducible factor-1α regulates the expression of nucleotide excision repair proteins in keratinocytes
por: Rezvani, Hamid Reza, et al.
Publicado: (2010)

Association of Age with the Expression of Hypoxia-Inducible Factors HIF-1α, HIF-2α, HIF-3α and VEGF in Lung and Heart of Tibetan Sheep
por: He, Yanyu, et al.
Publicado: (2019)

Distinct roles for the hypoxia-inducible transcription factors HIF-1α and HIF-2α in human osteoclast formation and function
por: Knowles, Helen J.
Publicado: (2020)

Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)
por: Thalhammer, Armin, et al.
Publicado: (2011)

HIF1α stabilization in hypoxia is not oxidant-initiated
por: Kumar, Amit, et al.
Publicado: (2021)

HIF-1α Is Associated with Resistance to Hypoxia-Induced Apoptosis in Ameloblastoma
por: Valladares, Katherine Julissa Palma, et al.
Publicado: (2021)

Role of hypoxia inducible factor HIF-1α in heart valves
por: Georgy, Mark, et al.
Publicado: (2023)

Characterization and functional analysis of hypoxia-inducible factor HIF1α and its inhibitor HIF1αn in tilapia
por: Li, Hong Lian, et al.
Publicado: (2017)

Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis
por: Yudoh, Kazuo, et al.
Publicado: (2005)

Genome-wide analysis reveals NRP1 as a direct HIF1α-E2F7 target in the regulation of motorneuron guidance in vivo
por: de Bruin, Alain, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_t6farae18i90rq3ib30kjts50j