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5-Lipoxygenase-mediated Endogenous DNA Damage

Lipoxygenases (LOs) convert polyunsaturated fatty acids into lipid hydroperoxides. Homolytic decomposition of lipid hydroperoxides gives rise to endogenous genotoxins such as 4-oxo-2(E)-nonenal, which cause the formation of mutagenic DNA adducts. Chiral lipidomics analysis was employed to show that...

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Detalles Bibliográficos
Autores principales:	Jian, Wenying, Lee, Seon Hwa, Williams, Michelle V., Blair, Ian A.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719316/ https://www.ncbi.nlm.nih.gov/pubmed/19390118 http://dx.doi.org/10.1074/jbc.M109.011841

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