Calcitonin Gene–Related Peptide and Thermal Injury: Review of Literature

The aim of this review article is to report about the anti-inflammatory properties of calcitonin gene–related peptide (CGRP) in burns. CGRP is a 37-amino acid neuropeptide, primarily released from sensory nerves and is well known as the most potent and long-lasting microvascular vasodilator in vitro and hypotensive agents in vivo. A wide range of proinflammatory stimuli can induce the release of neuropeptides from cutaneous sensory nerves, including heat, physical trauma, UV radiation, and irritant chemicals. These proinflammatory stimuli are known to induce the release of CGRP from cutaneous sensory nerves. The anti-inflammatory effects of CGRP in a range of species and in human clinical conditions are detailed, and potential therapeutic applications based on the use of antagonists and gene targeting of agonists are discussed.