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Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons

BACKGROUND: Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion mutation in the coding region of a novel gene. The mechanism of HD is unknown. Most data suggest that polyglutamine-mediated aggregation associated with expression of mutant huntin...

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Detalles Bibliográficos
Autores principales:	Trushina, Eugenia, Rana, Sandeep, McMurray, Cynthia T, Hua, Duy H
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719645/ https://www.ncbi.nlm.nih.gov/pubmed/19586540 http://dx.doi.org/10.1186/1471-2202-10-73

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