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Measurement of pharyngeal sensory cortical processing: technique and physiologic implications
BACKGROUND: Dysphagia is a major complication of different diseases affecting both the central and peripheral nervous system. Pharyngeal sensory impairment is one of the main features of neurogenic dysphagia. Therefore an objective technique to examine the cortical processing of pharyngeal sensory i...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719647/ https://www.ncbi.nlm.nih.gov/pubmed/19602264 http://dx.doi.org/10.1186/1471-2202-10-76 |
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author | Teismann, Inga K Steinstraeter, Olaf Warnecke, Tobias Ringelstein, E Bernd Pantev, Christo Dziewas, Rainer |
author_facet | Teismann, Inga K Steinstraeter, Olaf Warnecke, Tobias Ringelstein, E Bernd Pantev, Christo Dziewas, Rainer |
author_sort | Teismann, Inga K |
collection | PubMed |
description | BACKGROUND: Dysphagia is a major complication of different diseases affecting both the central and peripheral nervous system. Pharyngeal sensory impairment is one of the main features of neurogenic dysphagia. Therefore an objective technique to examine the cortical processing of pharyngeal sensory input would be a helpful diagnostic tool in this context. We developed a simple paradigm to perform pneumatic stimulation to both sides of the pharyngeal wall. Whole-head MEG was employed to study changes in cortical activation during this pharyngeal stimulation in nine healthy subjects. Data were analyzed by means of synthetic aperture magnetometry (SAM) and the group analysis of individual SAM data was performed using a permutation test. RESULTS: Our results revealed bilateral activation of the caudolateral primary somatosensory cortex following sensory pharyngeal stimulation with a slight lateralization to the side of stimulation. CONCLUSION: The method introduced here is simple and easy to perform and might be applicable in the clinical setting. The results are in keeping with previous findings showing bihemispheric involvement in the complex task of sensory pharyngeal processing. They might also explain changes in deglutition after hemispheric strokes. The ipsilaterally lateralized processing is surprising and needs further investigation. |
format | Text |
id | pubmed-2719647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27196472009-08-01 Measurement of pharyngeal sensory cortical processing: technique and physiologic implications Teismann, Inga K Steinstraeter, Olaf Warnecke, Tobias Ringelstein, E Bernd Pantev, Christo Dziewas, Rainer BMC Neurosci Research Article BACKGROUND: Dysphagia is a major complication of different diseases affecting both the central and peripheral nervous system. Pharyngeal sensory impairment is one of the main features of neurogenic dysphagia. Therefore an objective technique to examine the cortical processing of pharyngeal sensory input would be a helpful diagnostic tool in this context. We developed a simple paradigm to perform pneumatic stimulation to both sides of the pharyngeal wall. Whole-head MEG was employed to study changes in cortical activation during this pharyngeal stimulation in nine healthy subjects. Data were analyzed by means of synthetic aperture magnetometry (SAM) and the group analysis of individual SAM data was performed using a permutation test. RESULTS: Our results revealed bilateral activation of the caudolateral primary somatosensory cortex following sensory pharyngeal stimulation with a slight lateralization to the side of stimulation. CONCLUSION: The method introduced here is simple and easy to perform and might be applicable in the clinical setting. The results are in keeping with previous findings showing bihemispheric involvement in the complex task of sensory pharyngeal processing. They might also explain changes in deglutition after hemispheric strokes. The ipsilaterally lateralized processing is surprising and needs further investigation. BioMed Central 2009-07-14 /pmc/articles/PMC2719647/ /pubmed/19602264 http://dx.doi.org/10.1186/1471-2202-10-76 Text en Copyright © 2009 Teismann et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Teismann, Inga K Steinstraeter, Olaf Warnecke, Tobias Ringelstein, E Bernd Pantev, Christo Dziewas, Rainer Measurement of pharyngeal sensory cortical processing: technique and physiologic implications |
title | Measurement of pharyngeal sensory cortical processing: technique and physiologic implications |
title_full | Measurement of pharyngeal sensory cortical processing: technique and physiologic implications |
title_fullStr | Measurement of pharyngeal sensory cortical processing: technique and physiologic implications |
title_full_unstemmed | Measurement of pharyngeal sensory cortical processing: technique and physiologic implications |
title_short | Measurement of pharyngeal sensory cortical processing: technique and physiologic implications |
title_sort | measurement of pharyngeal sensory cortical processing: technique and physiologic implications |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719647/ https://www.ncbi.nlm.nih.gov/pubmed/19602264 http://dx.doi.org/10.1186/1471-2202-10-76 |
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