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An assessment of the portability of ancestry informative markers between human populations
BACKGROUND: Recent work has shown that population stratification can have confounding effects on genetic association studies and statistical methods have been developed to correct for these effects. Subsets of markers that are highly-differentiated between populations, ancestry-informative markers (...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719660/ https://www.ncbi.nlm.nih.gov/pubmed/19619313 http://dx.doi.org/10.1186/1755-8794-2-45 |
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author | Myles, Sean Stoneking, Mark Timpson, Nic |
author_facet | Myles, Sean Stoneking, Mark Timpson, Nic |
author_sort | Myles, Sean |
collection | PubMed |
description | BACKGROUND: Recent work has shown that population stratification can have confounding effects on genetic association studies and statistical methods have been developed to correct for these effects. Subsets of markers that are highly-differentiated between populations, ancestry-informative markers (AIMs), have been used to correct for population stratification. Often AIMs are discovered in one set of populations and then employed in a different set of populations. The underlying assumption in these cases is that the population under study has the same substructure as the population in which the AIMs were discovered. The present study assesses this assumption and evaluates the portability between worldwide populations of 10 SNPs found to be highly-differentiated within Britain (BritAIMs). METHODS: We genotyped 10 BritAIMs in ~1000 individuals from 53 populations worldwide. We assessed the degree to which these 10 BritAIMs capture population stratification in other groups of populations by use of the Fst statistic. We used Fst values from 2750 random markers typed in the same set of individuals as an empirical distribution to which the Fst values of the 10 BritAIMs were compared. RESULTS: Allele frequency differences between continental groups for the BritAIMs are not unusually high. This is also the case for comparisons within continental groups distantly related to Britain. However, two BritAIMs show high Fst between European populations and two BritAIMs show high Fst between populations from the Middle East. Overall the median Fst across all BritAIMs is not unusually high compared to the empirical distribution. CONCLUSION: We find that BritAIMs are generally not useful to distinguish between continental groups or within continental groups distantly related to Britain. Moreover, our analyses suggest that the portability of AIMs across geographical scales (e.g. between Europe and Britain) can be limited and should therefore be taken into consideration in the design and interpretation of genetic association studies. |
format | Text |
id | pubmed-2719660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27196602009-08-01 An assessment of the portability of ancestry informative markers between human populations Myles, Sean Stoneking, Mark Timpson, Nic BMC Med Genomics Research Article BACKGROUND: Recent work has shown that population stratification can have confounding effects on genetic association studies and statistical methods have been developed to correct for these effects. Subsets of markers that are highly-differentiated between populations, ancestry-informative markers (AIMs), have been used to correct for population stratification. Often AIMs are discovered in one set of populations and then employed in a different set of populations. The underlying assumption in these cases is that the population under study has the same substructure as the population in which the AIMs were discovered. The present study assesses this assumption and evaluates the portability between worldwide populations of 10 SNPs found to be highly-differentiated within Britain (BritAIMs). METHODS: We genotyped 10 BritAIMs in ~1000 individuals from 53 populations worldwide. We assessed the degree to which these 10 BritAIMs capture population stratification in other groups of populations by use of the Fst statistic. We used Fst values from 2750 random markers typed in the same set of individuals as an empirical distribution to which the Fst values of the 10 BritAIMs were compared. RESULTS: Allele frequency differences between continental groups for the BritAIMs are not unusually high. This is also the case for comparisons within continental groups distantly related to Britain. However, two BritAIMs show high Fst between European populations and two BritAIMs show high Fst between populations from the Middle East. Overall the median Fst across all BritAIMs is not unusually high compared to the empirical distribution. CONCLUSION: We find that BritAIMs are generally not useful to distinguish between continental groups or within continental groups distantly related to Britain. Moreover, our analyses suggest that the portability of AIMs across geographical scales (e.g. between Europe and Britain) can be limited and should therefore be taken into consideration in the design and interpretation of genetic association studies. BioMed Central 2009-07-20 /pmc/articles/PMC2719660/ /pubmed/19619313 http://dx.doi.org/10.1186/1755-8794-2-45 Text en Copyright © 2009 Myles et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Myles, Sean Stoneking, Mark Timpson, Nic An assessment of the portability of ancestry informative markers between human populations |
title | An assessment of the portability of ancestry informative markers between human populations |
title_full | An assessment of the portability of ancestry informative markers between human populations |
title_fullStr | An assessment of the portability of ancestry informative markers between human populations |
title_full_unstemmed | An assessment of the portability of ancestry informative markers between human populations |
title_short | An assessment of the portability of ancestry informative markers between human populations |
title_sort | assessment of the portability of ancestry informative markers between human populations |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719660/ https://www.ncbi.nlm.nih.gov/pubmed/19619313 http://dx.doi.org/10.1186/1755-8794-2-45 |
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