Virtual Terminator nucleotides for next generation DNA sequencing

We synthesized reversible terminators with tethered inhibitors for next generation sequencing. These were efficiently incorporated with high fidelity while preventing incorporation of additional nucleotides and were used to sequence canine bacterial artificial chromosomes in a single-molecule system...

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Detalles Bibliográficos
Autores principales: Bowers, Jayson, Mitchell, Judith, Beer, Eric, Buzby, Philip R., Causey, Marie, Efcavitch, J. William, Jarosz, Mirna, Krzymanska-Olejnik, Edyta, Kung, Li, Lipson, Doron, Lowman, Geoffrey M., Marappan, Subramanian, McInerney, Peter, Platt, Adam, Roy, Atanu, Siddiqi, Suhaib M., Steinmann, Kathleen, Thompson, John F.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719685/
https://www.ncbi.nlm.nih.gov/pubmed/19620973
http://dx.doi.org/10.1038/nmeth.1354

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