Vav Links the T Cell Antigen Receptor to the Actin Cytoskeleton and T Cell Activation Independently of Intrinsic Guanine Nucleotide Exchange Activity

BACKGROUND: T cell receptor (TCR) engagement leads to formation of signaling microclusters and induction of rapid and dynamic changes in the actin cytoskeleton, although the exact mechanism by which the TCR initiates actin polymerization is incompletely understood. The Vav family of guanine nucleoti...

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Detalles Bibliográficos
Autores principales: Miletic, Ana V., Graham, Daniel B., Sakata-Sogawa, Kumiko, Hiroshima, Michio, Hamann, Michael J., Cemerski, Saso, Kloeppel, Tracie, Billadeau, Daniel D., Kanagawa, Osami, Tokunaga, Makio, Swat, Wojciech
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719804/
https://www.ncbi.nlm.nih.gov/pubmed/19672294
http://dx.doi.org/10.1371/journal.pone.0006599

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