Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease

DNA methylation [1], [2] is capable of modulating coordinate expression of large numbers of genes across many different pathways, and may therefore warrant investigation for their potential role between genes and disease phenotype. In a rare set of monozygotic twins discordant for Alzheimer's d...

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Detalles Bibliográficos
Autores principales: Mastroeni, Diego, McKee, Ann, Grover, Andrew, Rogers, Joseph, Coleman, Paul D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719870/
https://www.ncbi.nlm.nih.gov/pubmed/19672297
http://dx.doi.org/10.1371/journal.pone.0006617
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author Mastroeni, Diego
McKee, Ann
Grover, Andrew
Rogers, Joseph
Coleman, Paul D.
author_facet Mastroeni, Diego
McKee, Ann
Grover, Andrew
Rogers, Joseph
Coleman, Paul D.
author_sort Mastroeni, Diego
collection PubMed
description DNA methylation [1], [2] is capable of modulating coordinate expression of large numbers of genes across many different pathways, and may therefore warrant investigation for their potential role between genes and disease phenotype. In a rare set of monozygotic twins discordant for Alzheimer's disease (AD), significantly reduced levels of DNA methylation were observed in temporal neocortex neuronal nuclei of the AD twin. These findings are consistent with the hypothesis that epigenetic mechanisms may mediate at the molecular level the effects of life events on AD risk, and provide, for the first time, a potential explanation for AD discordance despite genetic similarities.
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spelling pubmed-27198702009-08-12 Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease Mastroeni, Diego McKee, Ann Grover, Andrew Rogers, Joseph Coleman, Paul D. PLoS One Research Article DNA methylation [1], [2] is capable of modulating coordinate expression of large numbers of genes across many different pathways, and may therefore warrant investigation for their potential role between genes and disease phenotype. In a rare set of monozygotic twins discordant for Alzheimer's disease (AD), significantly reduced levels of DNA methylation were observed in temporal neocortex neuronal nuclei of the AD twin. These findings are consistent with the hypothesis that epigenetic mechanisms may mediate at the molecular level the effects of life events on AD risk, and provide, for the first time, a potential explanation for AD discordance despite genetic similarities. Public Library of Science 2009-08-12 /pmc/articles/PMC2719870/ /pubmed/19672297 http://dx.doi.org/10.1371/journal.pone.0006617 Text en Mastroeni et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Mastroeni, Diego
McKee, Ann
Grover, Andrew
Rogers, Joseph
Coleman, Paul D.
Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease
title Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease
title_full Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease
title_fullStr Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease
title_full_unstemmed Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease
title_short Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease
title_sort epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for alzheimer's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719870/
https://www.ncbi.nlm.nih.gov/pubmed/19672297
http://dx.doi.org/10.1371/journal.pone.0006617
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