CLRN1 Is Nonessential in the Mouse Retina but Is Required for Cochlear Hair Cell Development

Mutations in the CLRN1 gene cause Usher syndrome type 3 (USH3), a human disease characterized by progressive blindness and deafness. Clarin 1, the protein product of CLRN1, is a four-transmembrane protein predicted to be associated with ribbon synapses of photoreceptors and cochlear hair cells, and...

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Detalles Bibliográficos
Autores principales: Geller, Scott F., Guerin, Karen I., Visel, Meike, Pham, Aaron, Lee, Edwin S., Dror, Amiel A., Avraham, Karen B., Hayashi, Toshinori, Ray, Catherine A., Reh, Thomas A., Bermingham-McDonogh, Olivia, Triffo, William J., Bao, Shaowen, Isosomppi, Juha, Västinsalo, Hanna, Sankila, Eeva-Marja, Flannery, John G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719914/
https://www.ncbi.nlm.nih.gov/pubmed/19680541
http://dx.doi.org/10.1371/journal.pgen.1000607

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