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Episodic Src activation in uveal melanoma revealed by kinase activity profiling

BACKGROUND: The RAS/RAF/MEK/ERK pathway is involved in the balance between melanocyte proliferation and differentiation. The same pathway is constitutively activated in cutaneous and uveal melanoma (UM) and related to tumour growth and survival. Whereas mutant BRAF and NRAS are responsible for the a...

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Detalles Bibliográficos
Autores principales:	Maat, W, Filali, M el, Mulder, A Dirks-, Luyten, G P M, Gruis, N A, Desjardins, L, Boender, P, Jager, M J, van der Velden, P A
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720193/ https://www.ncbi.nlm.nih.gov/pubmed/19568237 http://dx.doi.org/10.1038/sj.bjc.6605172

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