Poly(ADP-ribose) polymerase-1 polymorphisms, expression and activity in selected human tumour cell lines

BACKGROUND: Poly(ADP-ribose) polymerase-1 (PARP-1) is a DNA-binding enzyme activated by DNA breaks and involved in DNA repair and other cellular processes. Poly(ADP-ribose) polymerase activity can be higher in cancer than in adjacent normal tissue, but cancer predisposition is reported to be greater...

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Detalles Bibliográficos
Autores principales: Zaremba, T, Ketzer, P, Cole, M, Coulthard, S, Plummer, E R, Curtin, N J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720202/
https://www.ncbi.nlm.nih.gov/pubmed/19568233
http://dx.doi.org/10.1038/sj.bjc.6605166

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