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Expression of a protease-resistant insulin-like growth factor-binding protein-4 inhibits tumour growth in a murine model of breast cancer

BACKGROUND: Insulin-like growth factor 1 (IGF1) promotes breast cancer and disease progression. Bioavailability of IGF1 is modulated by IGF-binding proteins (IGFBPs). IGFBP4 inhibits IGF1 activity but cleavage by pregnancy-associated plasma protein-A (PAPP-A) protease releases active IGF1. METHODS:...

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Detalles Bibliográficos
Autores principales:	Ryan, A J, Napoletano, S, Fitzpatrick, P A, Currid, C A, O'Sullivan, N C, Harmey, J H
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720214/ https://www.ncbi.nlm.nih.gov/pubmed/19536088 http://dx.doi.org/10.1038/sj.bjc.6605141

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