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MLH1 mediates PARP-dependent cell death in response to the methylating agent N-methyl-N-nitrosourea

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BACKGROUND: Methylating agents such as N-methyl-N-nitrosourea (MNU) can cause cell cycle arrest and death either via caspase-dependent apoptosis or via a poly(ADP-ribose) polymerase (PARP)-dependent form of apoptosis. We wished to investigate the possible role of MLH1 in signalling cell death throug...

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Detalles Bibliográficos
Autores principales:	McDaid, J R, Loughery, J, Dunne, P, Boyer, J C, Downes, C S, Farber, R A, Walsh, C P
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720233/ https://www.ncbi.nlm.nih.gov/pubmed/19623177 http://dx.doi.org/10.1038/sj.bjc.6605186

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