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Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma

BACKGROUND: Insulin-like growth factor (IGF)-I signalling stimulates proliferation, survival, and invasion in malignant mesothelioma and other tumour types. Studies have found that tumourigenesis is linked to dysregulation of cap-dependent protein translation. METHODS: The effect of IGF stimulation...

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Detalles Bibliográficos
Autores principales:	Jacobson, B A, De, A, Kratzke, M G, Patel, M R, Jay-Dixon, J, Whitson, B A, Sadiq, A A, Bitterman, P B, Polunovsky, V A, Kratzke, R A
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720234/ https://www.ncbi.nlm.nih.gov/pubmed/19603014 http://dx.doi.org/10.1038/sj.bjc.6605184

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