Epstein–Barr virus antibody level and gastric cancer risk in Korea: a nested case–control study

BACKGROUND: Few cohort studies have investigated Epstein–Barr virus (EBV) infection before the occurrence of gastric cancer. METHODS: Among 14 440 cohort participants, 100 incident gastric cancer cases were individually matched to two controls. Epstein–Barr virus antibodies IgG and IgA against viral...

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Autores principales: Kim, Y, Shin, A, Gwack, J, Ko, K-P, Kim, C-S, Park, S K, Hong, Y-C, Kang, D, Yoo, K-Y
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720236/
https://www.ncbi.nlm.nih.gov/pubmed/19550421
http://dx.doi.org/10.1038/sj.bjc.6605146
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author Kim, Y
Shin, A
Gwack, J
Ko, K-P
Kim, C-S
Park, S K
Hong, Y-C
Kang, D
Yoo, K-Y
author_facet Kim, Y
Shin, A
Gwack, J
Ko, K-P
Kim, C-S
Park, S K
Hong, Y-C
Kang, D
Yoo, K-Y
author_sort Kim, Y
collection PubMed
description BACKGROUND: Few cohort studies have investigated Epstein–Barr virus (EBV) infection before the occurrence of gastric cancer. METHODS: Among 14 440 cohort participants, 100 incident gastric cancer cases were individually matched to two controls. Epstein–Barr virus antibodies IgG and IgA against viral capsid antigen (VCA), EBV nuclear antigen (EBNA) antibody IgG, and early antigen (EA) antibody IgG were measured using enzyme immunoassays (EIAs). RESULTS: The highest titres of VCA IgG (odds ratio (OR): 1.37, 95% confidence interval (CI): 0.62–3.06) or EBNA IgG (OR: 0.87, 95% CI: 0.51–1.46) were not associated with gastric cancer risk. CONCLUSION: Higher levels of VCA IgG or EBNA IgG were not associated with increased risk of gastric adenocarcinoma in Koreans.
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spelling pubmed-27202362010-08-04 Epstein–Barr virus antibody level and gastric cancer risk in Korea: a nested case–control study Kim, Y Shin, A Gwack, J Ko, K-P Kim, C-S Park, S K Hong, Y-C Kang, D Yoo, K-Y Br J Cancer Short Communication BACKGROUND: Few cohort studies have investigated Epstein–Barr virus (EBV) infection before the occurrence of gastric cancer. METHODS: Among 14 440 cohort participants, 100 incident gastric cancer cases were individually matched to two controls. Epstein–Barr virus antibodies IgG and IgA against viral capsid antigen (VCA), EBV nuclear antigen (EBNA) antibody IgG, and early antigen (EA) antibody IgG were measured using enzyme immunoassays (EIAs). RESULTS: The highest titres of VCA IgG (odds ratio (OR): 1.37, 95% confidence interval (CI): 0.62–3.06) or EBNA IgG (OR: 0.87, 95% CI: 0.51–1.46) were not associated with gastric cancer risk. CONCLUSION: Higher levels of VCA IgG or EBNA IgG were not associated with increased risk of gastric adenocarcinoma in Koreans. Nature Publishing Group 2009-08-04 2009-06-23 /pmc/articles/PMC2720236/ /pubmed/19550421 http://dx.doi.org/10.1038/sj.bjc.6605146 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Kim, Y
Shin, A
Gwack, J
Ko, K-P
Kim, C-S
Park, S K
Hong, Y-C
Kang, D
Yoo, K-Y
Epstein–Barr virus antibody level and gastric cancer risk in Korea: a nested case–control study
title Epstein–Barr virus antibody level and gastric cancer risk in Korea: a nested case–control study
title_full Epstein–Barr virus antibody level and gastric cancer risk in Korea: a nested case–control study
title_fullStr Epstein–Barr virus antibody level and gastric cancer risk in Korea: a nested case–control study
title_full_unstemmed Epstein–Barr virus antibody level and gastric cancer risk in Korea: a nested case–control study
title_short Epstein–Barr virus antibody level and gastric cancer risk in Korea: a nested case–control study
title_sort epstein–barr virus antibody level and gastric cancer risk in korea: a nested case–control study
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720236/
https://www.ncbi.nlm.nih.gov/pubmed/19550421
http://dx.doi.org/10.1038/sj.bjc.6605146
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