Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer

BACKGROUND: Cyclooxygenase-2 (COX-2) is over-expressed in colorectal cancer (CRC), rendering tumour cells resistant to apoptosis. Selective COX-2 inhibition is effective in CRC prevention, although having adverse cardiovascular effects, thus focus has shifted to downstream pathways. METHODS: Microar...

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Detalles Bibliográficos
Autores principales: Doherty, G A, Byrne, S M, Austin, S C, Scully, G M, Sadlier, D M, Neilan, T G, Kay, E W, Murray, F E, Fitzgerald, D J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720240/
https://www.ncbi.nlm.nih.gov/pubmed/19638987
http://dx.doi.org/10.1038/sj.bjc.6605144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720240/
https://www.ncbi.nlm.nih.gov/pubmed/19638987
http://dx.doi.org/10.1038/sj.bjc.6605144

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