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Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer

BACKGROUND: Cyclooxygenase-2 (COX-2) is over-expressed in colorectal cancer (CRC), rendering tumour cells resistant to apoptosis. Selective COX-2 inhibition is effective in CRC prevention, although having adverse cardiovascular effects, thus focus has shifted to downstream pathways. METHODS: Microar...

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Detalles Bibliográficos
Autores principales:	Doherty, G A, Byrne, S M, Austin, S C, Scully, G M, Sadlier, D M, Neilan, T G, Kay, E W, Murray, F E, Fitzgerald, D J
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720240/ https://www.ncbi.nlm.nih.gov/pubmed/19638987 http://dx.doi.org/10.1038/sj.bjc.6605144

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