Ascending aortic aneurysm in a patient with bicuspid aortic valve, positive history of systemic autoimmune diseases and common genetic factors: a case report

The bicuspid aortic valve (BAV) and specific systemic autoimmune diseases are associated with cardiovascular manifestation, including aortic aneurysm. We reported a case of 64 year-old patient with BAV and a history of ankylosing spondylitis (AS) and systemic lupus erythematosus (SLE), and who devel...

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Autores principales: Foffa, Ilenia, Festa, Pier Luigi, Ait-Ali, Lamia, Mazzone, Annamaria, Bevilacqua, Stefano, Andreassi, Maria Grazia
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720381/
https://www.ncbi.nlm.nih.gov/pubmed/19580662
http://dx.doi.org/10.1186/1476-7120-7-34
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author Foffa, Ilenia
Festa, Pier Luigi
Ait-Ali, Lamia
Mazzone, Annamaria
Bevilacqua, Stefano
Andreassi, Maria Grazia
author_facet Foffa, Ilenia
Festa, Pier Luigi
Ait-Ali, Lamia
Mazzone, Annamaria
Bevilacqua, Stefano
Andreassi, Maria Grazia
author_sort Foffa, Ilenia
collection PubMed
description The bicuspid aortic valve (BAV) and specific systemic autoimmune diseases are associated with cardiovascular manifestation, including aortic aneurysm. We reported a case of 64 year-old patient with BAV and a history of ankylosing spondylitis (AS) and systemic lupus erythematosus (SLE), and who developed ascending thoracic aortic aneurysm. The patient presented also the homozygosity for genetic variants of MMP9, ACE, MTHFR and PAI-1 genes. Gene-environmental interactions may represent an additional pathogenetic dimension in the still challenging management of the abnormalities of the aortic wall, including dilatation, aneurysm and dissection.
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spelling pubmed-27203812009-08-04 Ascending aortic aneurysm in a patient with bicuspid aortic valve, positive history of systemic autoimmune diseases and common genetic factors: a case report Foffa, Ilenia Festa, Pier Luigi Ait-Ali, Lamia Mazzone, Annamaria Bevilacqua, Stefano Andreassi, Maria Grazia Cardiovasc Ultrasound Case Report The bicuspid aortic valve (BAV) and specific systemic autoimmune diseases are associated with cardiovascular manifestation, including aortic aneurysm. We reported a case of 64 year-old patient with BAV and a history of ankylosing spondylitis (AS) and systemic lupus erythematosus (SLE), and who developed ascending thoracic aortic aneurysm. The patient presented also the homozygosity for genetic variants of MMP9, ACE, MTHFR and PAI-1 genes. Gene-environmental interactions may represent an additional pathogenetic dimension in the still challenging management of the abnormalities of the aortic wall, including dilatation, aneurysm and dissection. BioMed Central 2009-07-06 /pmc/articles/PMC2720381/ /pubmed/19580662 http://dx.doi.org/10.1186/1476-7120-7-34 Text en Copyright © 2009 Foffa et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Foffa, Ilenia
Festa, Pier Luigi
Ait-Ali, Lamia
Mazzone, Annamaria
Bevilacqua, Stefano
Andreassi, Maria Grazia
Ascending aortic aneurysm in a patient with bicuspid aortic valve, positive history of systemic autoimmune diseases and common genetic factors: a case report
title Ascending aortic aneurysm in a patient with bicuspid aortic valve, positive history of systemic autoimmune diseases and common genetic factors: a case report
title_full Ascending aortic aneurysm in a patient with bicuspid aortic valve, positive history of systemic autoimmune diseases and common genetic factors: a case report
title_fullStr Ascending aortic aneurysm in a patient with bicuspid aortic valve, positive history of systemic autoimmune diseases and common genetic factors: a case report
title_full_unstemmed Ascending aortic aneurysm in a patient with bicuspid aortic valve, positive history of systemic autoimmune diseases and common genetic factors: a case report
title_short Ascending aortic aneurysm in a patient with bicuspid aortic valve, positive history of systemic autoimmune diseases and common genetic factors: a case report
title_sort ascending aortic aneurysm in a patient with bicuspid aortic valve, positive history of systemic autoimmune diseases and common genetic factors: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720381/
https://www.ncbi.nlm.nih.gov/pubmed/19580662
http://dx.doi.org/10.1186/1476-7120-7-34
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