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Biomarkers for early detection of high risk cancers: From gliomas to nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NpC) is a malignant disease associated with Epstein-Barr virus infection, and often diagnosed at an advanced stage. This significantly curtails patient survival. We hypothesize that a panel of biomarkers can be assembled to assess NpC incidence, early detection, and tumor p...

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Detalles Bibliográficos
Autores principales: Oluwadara, Oluwadayo, Chiappelli, Francesco
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics Publishing Group 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720668/
https://www.ncbi.nlm.nih.gov/pubmed/19707295
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author Oluwadara, Oluwadayo
Chiappelli, Francesco
author_facet Oluwadara, Oluwadayo
Chiappelli, Francesco
author_sort Oluwadara, Oluwadayo
collection PubMed
description Nasopharyngeal carcinoma (NpC) is a malignant disease associated with Epstein-Barr virus infection, and often diagnosed at an advanced stage. This significantly curtails patient survival. We hypothesize that a panel of biomarkers can be assembled to assess NpC incidence, early detection, and tumor progression during therapeutic intervention. Our thesis rests on a model of successfully predicting high-risk gliomas by means of a carefully crafted panel of molecular mitotic biomarkers (i.e., securin, survivin and MCM2). The strategy we propose holds strong promise for prevention and cure of NpC. The approach we propose seeks to identify certain biomarkers from viral materials, patient tissues and assessment of related diseases, whose signatures, taken together, will be endowed with some degree of congruency, or sense of a coordinated language (i.e., “votes”). Biomarker “voting” will then permit to outline a broad coordinated molecular map for the molecular and epigenetic characterization of each individual patient's NpC tumor. We will draw on the process of contrasting biomarkers in health and disease, which rests on the auto-proteomic concept particularly relevant in high-risk cancer individuals, such as is the case for NpC. In brief we defend, current advances in human proteome profiling proffers the possibility of having individual baseline proteomic profiles using local body fluids (e.g., saliva, nasal secretions, sputum) or systemic fluids (e.g., plasma, serum, cerebrospinal fluid) to unravel a personalized molecular map for high-risk NpC individuals. Regular check-up will monitor for new or impending manifestations of NpC, and provide a secure assessment of incidence and early detection.
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spelling pubmed-27206682009-08-25 Biomarkers for early detection of high risk cancers: From gliomas to nasopharyngeal carcinoma Oluwadara, Oluwadayo Chiappelli, Francesco Bioinformation Hypothesis Nasopharyngeal carcinoma (NpC) is a malignant disease associated with Epstein-Barr virus infection, and often diagnosed at an advanced stage. This significantly curtails patient survival. We hypothesize that a panel of biomarkers can be assembled to assess NpC incidence, early detection, and tumor progression during therapeutic intervention. Our thesis rests on a model of successfully predicting high-risk gliomas by means of a carefully crafted panel of molecular mitotic biomarkers (i.e., securin, survivin and MCM2). The strategy we propose holds strong promise for prevention and cure of NpC. The approach we propose seeks to identify certain biomarkers from viral materials, patient tissues and assessment of related diseases, whose signatures, taken together, will be endowed with some degree of congruency, or sense of a coordinated language (i.e., “votes”). Biomarker “voting” will then permit to outline a broad coordinated molecular map for the molecular and epigenetic characterization of each individual patient's NpC tumor. We will draw on the process of contrasting biomarkers in health and disease, which rests on the auto-proteomic concept particularly relevant in high-risk cancer individuals, such as is the case for NpC. In brief we defend, current advances in human proteome profiling proffers the possibility of having individual baseline proteomic profiles using local body fluids (e.g., saliva, nasal secretions, sputum) or systemic fluids (e.g., plasma, serum, cerebrospinal fluid) to unravel a personalized molecular map for high-risk NpC individuals. Regular check-up will monitor for new or impending manifestations of NpC, and provide a secure assessment of incidence and early detection. Biomedical Informatics Publishing Group 2009-04-21 /pmc/articles/PMC2720668/ /pubmed/19707295 Text en © 2009 Biomedical Informatics Publishing Group This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Oluwadara, Oluwadayo
Chiappelli, Francesco
Biomarkers for early detection of high risk cancers: From gliomas to nasopharyngeal carcinoma
title Biomarkers for early detection of high risk cancers: From gliomas to nasopharyngeal carcinoma
title_full Biomarkers for early detection of high risk cancers: From gliomas to nasopharyngeal carcinoma
title_fullStr Biomarkers for early detection of high risk cancers: From gliomas to nasopharyngeal carcinoma
title_full_unstemmed Biomarkers for early detection of high risk cancers: From gliomas to nasopharyngeal carcinoma
title_short Biomarkers for early detection of high risk cancers: From gliomas to nasopharyngeal carcinoma
title_sort biomarkers for early detection of high risk cancers: from gliomas to nasopharyngeal carcinoma
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720668/
https://www.ncbi.nlm.nih.gov/pubmed/19707295
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