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Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells

Apoptosis is a common pathway that finally mediated the killing functions of anticancer drugs, which is an important cause of multidrug resistance (MDR). The aim of this study was to investigate the potential benefit of combination therapy with magnetic nanoparticle of Fe(3)O(4) (MNP(Fe(3)O(4))) and...

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Detalles Bibliográficos
Autores principales: Chen, Baoan, Cheng, Jian, Shen, Mingfang, Gao, Feng, Xu, Wenlin, Shen, Huilin, Ding, Jiahua, Gao, Chong, Sun, Qian, Sun, Xinchen, Cheng, Hongyan, Li, Guohong, Chen, Wenji, Chen, Ningna, Liu, Lijie, Li, Xiaomao, Wang, Xuemei
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720739/
https://www.ncbi.nlm.nih.gov/pubmed/19421371
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author Chen, Baoan
Cheng, Jian
Shen, Mingfang
Gao, Feng
Xu, Wenlin
Shen, Huilin
Ding, Jiahua
Gao, Chong
Sun, Qian
Sun, Xinchen
Cheng, Hongyan
Li, Guohong
Chen, Wenji
Chen, Ningna
Liu, Lijie
Li, Xiaomao
Wang, Xuemei
author_facet Chen, Baoan
Cheng, Jian
Shen, Mingfang
Gao, Feng
Xu, Wenlin
Shen, Huilin
Ding, Jiahua
Gao, Chong
Sun, Qian
Sun, Xinchen
Cheng, Hongyan
Li, Guohong
Chen, Wenji
Chen, Ningna
Liu, Lijie
Li, Xiaomao
Wang, Xuemei
author_sort Chen, Baoan
collection PubMed
description Apoptosis is a common pathway that finally mediated the killing functions of anticancer drugs, which is an important cause of multidrug resistance (MDR). The aim of this study was to investigate the potential benefit of combination therapy with magnetic nanoparticle of Fe(3)O(4) (MNP(Fe(3)O(4))) and 5-bromotetrandrin (BrTet). Analysis of the apoptosis percentage showed that combination of daunorubicin (DNR) with either MNP(Fe(3)O(4)) or BrTet exerted a potent cytotoxic effect on K562/A02 cells, while MNP(Fe(3)O(4)) and BrTet cotreatment can synergistically enhance DNR-induced apoptosis. Importantly, we confirmed that the distinct synergism effect of that composite on reverse multidrug resistance may owe to the regulation of various proliferative and antiapoptotic gene products, including P53 and caspase-3. Thus our in vitro data strongly suggests a potential clinical application of MNP(Fe(3)O(4)) and BrTet combination on CML.
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spelling pubmed-27207392009-08-31 Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells Chen, Baoan Cheng, Jian Shen, Mingfang Gao, Feng Xu, Wenlin Shen, Huilin Ding, Jiahua Gao, Chong Sun, Qian Sun, Xinchen Cheng, Hongyan Li, Guohong Chen, Wenji Chen, Ningna Liu, Lijie Li, Xiaomao Wang, Xuemei Int J Nanomedicine Original Research Apoptosis is a common pathway that finally mediated the killing functions of anticancer drugs, which is an important cause of multidrug resistance (MDR). The aim of this study was to investigate the potential benefit of combination therapy with magnetic nanoparticle of Fe(3)O(4) (MNP(Fe(3)O(4))) and 5-bromotetrandrin (BrTet). Analysis of the apoptosis percentage showed that combination of daunorubicin (DNR) with either MNP(Fe(3)O(4)) or BrTet exerted a potent cytotoxic effect on K562/A02 cells, while MNP(Fe(3)O(4)) and BrTet cotreatment can synergistically enhance DNR-induced apoptosis. Importantly, we confirmed that the distinct synergism effect of that composite on reverse multidrug resistance may owe to the regulation of various proliferative and antiapoptotic gene products, including P53 and caspase-3. Thus our in vitro data strongly suggests a potential clinical application of MNP(Fe(3)O(4)) and BrTet combination on CML. Dove Medical Press 2009 2009-04-01 /pmc/articles/PMC2720739/ /pubmed/19421371 Text en © 2009 Dove Medical Press Limited. All rights reserved
spellingShingle Original Research
Chen, Baoan
Cheng, Jian
Shen, Mingfang
Gao, Feng
Xu, Wenlin
Shen, Huilin
Ding, Jiahua
Gao, Chong
Sun, Qian
Sun, Xinchen
Cheng, Hongyan
Li, Guohong
Chen, Wenji
Chen, Ningna
Liu, Lijie
Li, Xiaomao
Wang, Xuemei
Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
title Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
title_full Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
title_fullStr Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
title_full_unstemmed Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
title_short Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
title_sort magnetic nanoparticle of fe(3)o(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720739/
https://www.ncbi.nlm.nih.gov/pubmed/19421371
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