Cargando…
Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
Apoptosis is a common pathway that finally mediated the killing functions of anticancer drugs, which is an important cause of multidrug resistance (MDR). The aim of this study was to investigate the potential benefit of combination therapy with magnetic nanoparticle of Fe(3)O(4) (MNP(Fe(3)O(4))) and...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720739/ https://www.ncbi.nlm.nih.gov/pubmed/19421371 |
_version_ | 1782170146075312128 |
---|---|
author | Chen, Baoan Cheng, Jian Shen, Mingfang Gao, Feng Xu, Wenlin Shen, Huilin Ding, Jiahua Gao, Chong Sun, Qian Sun, Xinchen Cheng, Hongyan Li, Guohong Chen, Wenji Chen, Ningna Liu, Lijie Li, Xiaomao Wang, Xuemei |
author_facet | Chen, Baoan Cheng, Jian Shen, Mingfang Gao, Feng Xu, Wenlin Shen, Huilin Ding, Jiahua Gao, Chong Sun, Qian Sun, Xinchen Cheng, Hongyan Li, Guohong Chen, Wenji Chen, Ningna Liu, Lijie Li, Xiaomao Wang, Xuemei |
author_sort | Chen, Baoan |
collection | PubMed |
description | Apoptosis is a common pathway that finally mediated the killing functions of anticancer drugs, which is an important cause of multidrug resistance (MDR). The aim of this study was to investigate the potential benefit of combination therapy with magnetic nanoparticle of Fe(3)O(4) (MNP(Fe(3)O(4))) and 5-bromotetrandrin (BrTet). Analysis of the apoptosis percentage showed that combination of daunorubicin (DNR) with either MNP(Fe(3)O(4)) or BrTet exerted a potent cytotoxic effect on K562/A02 cells, while MNP(Fe(3)O(4)) and BrTet cotreatment can synergistically enhance DNR-induced apoptosis. Importantly, we confirmed that the distinct synergism effect of that composite on reverse multidrug resistance may owe to the regulation of various proliferative and antiapoptotic gene products, including P53 and caspase-3. Thus our in vitro data strongly suggests a potential clinical application of MNP(Fe(3)O(4)) and BrTet combination on CML. |
format | Text |
id | pubmed-2720739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-27207392009-08-31 Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells Chen, Baoan Cheng, Jian Shen, Mingfang Gao, Feng Xu, Wenlin Shen, Huilin Ding, Jiahua Gao, Chong Sun, Qian Sun, Xinchen Cheng, Hongyan Li, Guohong Chen, Wenji Chen, Ningna Liu, Lijie Li, Xiaomao Wang, Xuemei Int J Nanomedicine Original Research Apoptosis is a common pathway that finally mediated the killing functions of anticancer drugs, which is an important cause of multidrug resistance (MDR). The aim of this study was to investigate the potential benefit of combination therapy with magnetic nanoparticle of Fe(3)O(4) (MNP(Fe(3)O(4))) and 5-bromotetrandrin (BrTet). Analysis of the apoptosis percentage showed that combination of daunorubicin (DNR) with either MNP(Fe(3)O(4)) or BrTet exerted a potent cytotoxic effect on K562/A02 cells, while MNP(Fe(3)O(4)) and BrTet cotreatment can synergistically enhance DNR-induced apoptosis. Importantly, we confirmed that the distinct synergism effect of that composite on reverse multidrug resistance may owe to the regulation of various proliferative and antiapoptotic gene products, including P53 and caspase-3. Thus our in vitro data strongly suggests a potential clinical application of MNP(Fe(3)O(4)) and BrTet combination on CML. Dove Medical Press 2009 2009-04-01 /pmc/articles/PMC2720739/ /pubmed/19421371 Text en © 2009 Dove Medical Press Limited. All rights reserved |
spellingShingle | Original Research Chen, Baoan Cheng, Jian Shen, Mingfang Gao, Feng Xu, Wenlin Shen, Huilin Ding, Jiahua Gao, Chong Sun, Qian Sun, Xinchen Cheng, Hongyan Li, Guohong Chen, Wenji Chen, Ningna Liu, Lijie Li, Xiaomao Wang, Xuemei Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells |
title | Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells |
title_full | Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells |
title_fullStr | Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells |
title_full_unstemmed | Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells |
title_short | Magnetic nanoparticle of Fe(3)O(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells |
title_sort | magnetic nanoparticle of fe(3)o(4) and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720739/ https://www.ncbi.nlm.nih.gov/pubmed/19421371 |
work_keys_str_mv | AT chenbaoan magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT chengjian magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT shenmingfang magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT gaofeng magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT xuwenlin magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT shenhuilin magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT dingjiahua magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT gaochong magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT sunqian magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT sunxinchen magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT chenghongyan magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT liguohong magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT chenwenji magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT chenningna magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT liulijie magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT lixiaomao magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT wangxuemei magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells |