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The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice
We evaluated the antidiabetic effects of a mixed vegetable powder-formula I (MVP-FI), which is a dry powder mixture of over 65 kinds of vegetables and fruits, using the db/db type 2 diabetes mouse model. The db/db mice at 8–10 weeks of age were randomly divided into three groups: vehicle treatment,...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721366/ https://www.ncbi.nlm.nih.gov/pubmed/19707387 |
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author | Yeung, Chung-Man Tan, Yi Tam, Sidney Lu, Liwei Ko, King-Hung Yang, Pai-Hao Kung, Hsiang-Fu Lin, Marie C |
author_facet | Yeung, Chung-Man Tan, Yi Tam, Sidney Lu, Liwei Ko, King-Hung Yang, Pai-Hao Kung, Hsiang-Fu Lin, Marie C |
author_sort | Yeung, Chung-Man |
collection | PubMed |
description | We evaluated the antidiabetic effects of a mixed vegetable powder-formula I (MVP-FI), which is a dry powder mixture of over 65 kinds of vegetables and fruits, using the db/db type 2 diabetes mouse model. The db/db mice at 8–10 weeks of age were randomly divided into three groups: vehicle treatment, 1.575 g/kg MVP-FI treatment, and 3.15 g/kg MVP-FI treatment. During 12 days of treatment, we measured food intake and body weight changes, fasting blood glucose levels, and plasma lipid levels. Our results showed that the food intake and the body weight of MVP-FI-treated group were decreased gradually. Moreover, the fasting blood glucose level of the treated group was significantly dropped to a normal level comparable to that of the lean mice. Furthermore, we also found that the plasma triglyceride level in the treated group was dropped, whereas the high-density lipoprotein (HDL) level was increased and total cholesterol/HDL-cholesterol ratio was decreased. Taken together, these results suggest that the diabetic conditions of the db/db mice have been improved after 12 days treatment with MVP-FI. The antihyperglycemic and antiobese activities of the MVP-FI, as demonstrated in the present study, may have important clinical implications for improving the management of type 2 diabetic patients. |
format | Text |
id | pubmed-2721366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-27213662009-08-25 The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice Yeung, Chung-Man Tan, Yi Tam, Sidney Lu, Liwei Ko, King-Hung Yang, Pai-Hao Kung, Hsiang-Fu Lin, Marie C Biologics Original Research We evaluated the antidiabetic effects of a mixed vegetable powder-formula I (MVP-FI), which is a dry powder mixture of over 65 kinds of vegetables and fruits, using the db/db type 2 diabetes mouse model. The db/db mice at 8–10 weeks of age were randomly divided into three groups: vehicle treatment, 1.575 g/kg MVP-FI treatment, and 3.15 g/kg MVP-FI treatment. During 12 days of treatment, we measured food intake and body weight changes, fasting blood glucose levels, and plasma lipid levels. Our results showed that the food intake and the body weight of MVP-FI-treated group were decreased gradually. Moreover, the fasting blood glucose level of the treated group was significantly dropped to a normal level comparable to that of the lean mice. Furthermore, we also found that the plasma triglyceride level in the treated group was dropped, whereas the high-density lipoprotein (HDL) level was increased and total cholesterol/HDL-cholesterol ratio was decreased. Taken together, these results suggest that the diabetic conditions of the db/db mice have been improved after 12 days treatment with MVP-FI. The antihyperglycemic and antiobese activities of the MVP-FI, as demonstrated in the present study, may have important clinical implications for improving the management of type 2 diabetic patients. Dove Medical Press 2008-09 2008-09 /pmc/articles/PMC2721366/ /pubmed/19707387 Text en © 2008 Yeung et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Yeung, Chung-Man Tan, Yi Tam, Sidney Lu, Liwei Ko, King-Hung Yang, Pai-Hao Kung, Hsiang-Fu Lin, Marie C The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice |
title | The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice |
title_full | The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice |
title_fullStr | The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice |
title_full_unstemmed | The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice |
title_short | The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice |
title_sort | antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721366/ https://www.ncbi.nlm.nih.gov/pubmed/19707387 |
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