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Selective P2X(7) receptor antagonists for chronic inflammation and pain
ATP, acting on P2X(7) receptors, stimulates changes in intracellular calcium concentrations, maturation, and release of interleukin-1β (IL-1β), and following prolonged agonist exposure, cell death. The functional effects of P2X(7) receptor activation facilitate several proinflammatory processes asso...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Springer Netherlands
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721772/ https://www.ncbi.nlm.nih.gov/pubmed/18568426 http://dx.doi.org/10.1007/s11302-008-9110-6 |