Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

Plk1 plays a pivotal role in cell proliferation and is considered an attractive target for anti-cancer therapy. The noncatalytic polo-box domain (PBD) of Plk1 forms a phosphoepitope-binding module for protein-protein interaction. Here, we report the identification of minimal phosphopeptides that spe...

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Detalles Bibliográficos
Autores principales: Yun, Sang-Moon, Moulaei, Tinoush, Lim, Dan, Bang, Jeong K., Park, Jung-Eun, Shenoy, Shilpa R., Liu, Fa, Kang, Young Hwi, Liao, Chenzhong, Soung, Nak-Kyun, Lee, Sunhee, Yoon, Do-Young, Lim, Yoongho, Lee, Dong-Hee, Otaka, Akira, Appella, Ettore, McMahon, James B., Nicklaus, Marc C., Burke, Terrence R., Yaffe, Michael B., Wlodawer, Alexander, Lee, Kyung S.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721907/
https://www.ncbi.nlm.nih.gov/pubmed/19597481
http://dx.doi.org/10.1038/nsmb.1628

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