Cargando…

Multiple functions of MRN in end-joining pathways during isotype class switching

The Mre11/Rad50/NBS1 (MRN) complex plays many roles in response to DNA double strand breaks (DSBs), but its functions in repair by non homologous end joining (NHEJ) pathways are poorly understood. We have investigated requirements for MRN in Class Switch Recombination (CSR), a programmed DNA rearran...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dinkelmann, Maria, Spehalski, Elizabeth, Stoneham, Trina, Buis, Jeffrey, Wu, Yipin, Sekiguchi, JoAnn M., Ferguson, David O.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721910/ https://www.ncbi.nlm.nih.gov/pubmed/19633670 http://dx.doi.org/10.1038/nsmb.1639

Ejemplares similares

Mre11 regulates CtIP–dependent double strand break repair by interaction with CDK2
por: Buis, Jeffrey, et al.
Publicado: (2012)

DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining
por: Cabrini, Matteo, et al.
Publicado: (2021)

Non-homologous end joining in class switch recombination: the beginning of the end
por: Kotnis, Ashwin, et al.
Publicado: (2008)

Evidence for Class-Specific Factors in Immunoglobulin Isotype Switching
por: Shanmugam, Ananth, et al.
Publicado: (2000)

CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1
por: Quennet, Verena, et al.
Publicado: (2011)

Involvement of Artemis in nonhomologous end-joining during immunoglobulin class switch recombination
por: Du, Likun, et al.
Publicado: (2008)

The Liaison of Isotype Class Switch and Mismatch Repair: An Illegitimate Affair
por: Kenter, Amy L.
Publicado: (1999)

Switch Tandem Repeats Influence the Choice of the Alternative End-Joining Pathway in Immunoglobulin Class Switch Recombination
por: Oudinet, Chloé, et al.
Publicado: (2022)

Multiple DSB Resection Activities Redundantly Promote Alternative End Joining-Mediated Class Switch Recombination
por: Sun, Xikui, et al.
Publicado: (2021)

Ikaros controls isotype selection during immunoglobulin class switch recombination
por: Sellars, MacLean, et al.
Publicado: (2009)

CtIP promotes microhomology-mediated alternative end-joining during class switch recombination
por: Lee-Theilen, Mieun, et al.
Publicado: (2010)

DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination
por: Franco, Sonia, et al.
Publicado: (2008)

Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV–deficient B cells
por: Han, Li, et al.
Publicado: (2008)

Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV–deficient B cells
por: Han, Li, et al.
Publicado: (2008)

Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome
por: Helfricht, Angela, et al.
Publicado: (2020)

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells
por: Pan-Hammarström, Qiang, et al.
Publicado: (2005)

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
por: Boboila, Cristian, et al.
Publicado: (2010)

A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination
por: Enervald, Elin, et al.
Publicado: (2013)

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
por: Boboila, Cristian, et al.
Publicado: (2013)

The Multiple Faces of the MRN Complex: Roles in Medulloblastoma and Beyond
por: Petroni, Marialaura, et al.
Publicado: (2023)

DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP
por: Deshpande, Rajashree A., et al.
Publicado: (2020)

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
por: Bothmer, Anne, et al.
Publicado: (2010)

The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
por: Li, Conglei, et al.
Publicado: (2018)

DNA polymerase beta participates in DNA End-joining
por: Ray, Sreerupa, et al.
Publicado: (2018)

Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny
por: Kumar, Satyendra, et al.
Publicado: (2013)

Antigen structural requirements for immunoglobulin isotype switching in mice
por: Chen, P, et al.
Publicado: (1980)

Loop extrusion promotes an alternate pathway for isotype switching
por: Shen, Hong Ming, et al.
Publicado: (2021)

Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching
por: Dong, Junchao, et al.
Publicado: (2015)

The spatial organization of non-homologous end joining: From bridging to end joining
por: Ochi, Takashi, et al.
Publicado: (2014)

DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres
por: Myler, Logan R., et al.
Publicado: (2023)

TACI and BAFF-R mediate isotype switching in B cells
por: Castigli, Emanuela, et al.
Publicado: (2005)

Microhomology-mediated end joining: new players join the team
por: Wang, Hailong, et al.
Publicado: (2017)

Inhibition of MRN activity by a telomere protein motif
por: Khayat, Freddy, et al.
Publicado: (2021)

Recruitment and activation of the ATM kinase in the absence of DNA damage sensors
por: Hartlerode, Andrea J., et al.
Publicado: (2015)

B cell differentiation and isotype switching is related to division cycle number
Publicado: (1996)

Idiotope regulation by isotype switch variants of two monoclonal antiidiotope antibodies
Publicado: (1984)

Antibody Isotype Switching as a Mechanism to Counter HIV Neutralization Escape
por: Scheepers, Cathrine, et al.
Publicado: (2020)

Making ends meet in class switch recombination
por: Wu, Lizhen, et al.
Publicado: (2020)

Resolution of complex ends by Nonhomologous end joining - better to be lucky than good?
por: Strande, Natasha Tiffany, et al.
Publicado: (2012)

The Essential DNA Damage Response Complex MRN Is Dispensable for the Survival and Function of Purkinje Neurons
por: Ding, Mingmei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_c4fdcbg6ia8v0mpaprjn9jdvjk