Lack of Toll-like Receptor 4 and 2 Polymorphisms in Korean Patients with Bacteremia

Toll-like receptors (TLRs) are pattern-recognition receptors that are important in innate immune responses to bacterial infection. The purpose of this study is to describe the prevalence of TLRs genetic variations in the bacteremic patients in Korea. A total of 154 patients with bacteremia and 179 h...

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Autores principales: Yoon, Hee Jung, Choi, Jun Yong, Kim, Chang Oh, Park, Yoon Seon, Kim, Myoung Soo, Kim, Young Keun, Shin, So Youn, Kim, June Myung, Song, Young Goo
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2006
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721950/
https://www.ncbi.nlm.nih.gov/pubmed/17179672
http://dx.doi.org/10.3346/jkms.2006.21.6.979
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author Yoon, Hee Jung
Choi, Jun Yong
Kim, Chang Oh
Park, Yoon Seon
Kim, Myoung Soo
Kim, Young Keun
Shin, So Youn
Kim, June Myung
Song, Young Goo
author_facet Yoon, Hee Jung
Choi, Jun Yong
Kim, Chang Oh
Park, Yoon Seon
Kim, Myoung Soo
Kim, Young Keun
Shin, So Youn
Kim, June Myung
Song, Young Goo
author_sort Yoon, Hee Jung
collection PubMed
description Toll-like receptors (TLRs) are pattern-recognition receptors that are important in innate immune responses to bacterial infection. The purpose of this study is to describe the prevalence of TLRs genetic variations in the bacteremic patients in Korea. A total of 154 patients with bacteremia and 179 healthy volunteers were included. The Asp299Gly and Thr399Ile allele of the TLR4 gene and Arg753Gln and Arg677Trp allele of the TLR2 gene were tested by PCR-RFLP. The DNA sequences were determined to confirm the PCR-RFLP results. Contrary to the expectation, no genetic polymorphisms were detected in both groups of this study, suggesting that it is very rare in Korean.
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spelling pubmed-27219502009-08-07 Lack of Toll-like Receptor 4 and 2 Polymorphisms in Korean Patients with Bacteremia Yoon, Hee Jung Choi, Jun Yong Kim, Chang Oh Park, Yoon Seon Kim, Myoung Soo Kim, Young Keun Shin, So Youn Kim, June Myung Song, Young Goo J Korean Med Sci Original Article Toll-like receptors (TLRs) are pattern-recognition receptors that are important in innate immune responses to bacterial infection. The purpose of this study is to describe the prevalence of TLRs genetic variations in the bacteremic patients in Korea. A total of 154 patients with bacteremia and 179 healthy volunteers were included. The Asp299Gly and Thr399Ile allele of the TLR4 gene and Arg753Gln and Arg677Trp allele of the TLR2 gene were tested by PCR-RFLP. The DNA sequences were determined to confirm the PCR-RFLP results. Contrary to the expectation, no genetic polymorphisms were detected in both groups of this study, suggesting that it is very rare in Korean. The Korean Academy of Medical Sciences 2006-12 2006-12-31 /pmc/articles/PMC2721950/ /pubmed/17179672 http://dx.doi.org/10.3346/jkms.2006.21.6.979 Text en Copyright © 2006 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yoon, Hee Jung
Choi, Jun Yong
Kim, Chang Oh
Park, Yoon Seon
Kim, Myoung Soo
Kim, Young Keun
Shin, So Youn
Kim, June Myung
Song, Young Goo
Lack of Toll-like Receptor 4 and 2 Polymorphisms in Korean Patients with Bacteremia
title Lack of Toll-like Receptor 4 and 2 Polymorphisms in Korean Patients with Bacteremia
title_full Lack of Toll-like Receptor 4 and 2 Polymorphisms in Korean Patients with Bacteremia
title_fullStr Lack of Toll-like Receptor 4 and 2 Polymorphisms in Korean Patients with Bacteremia
title_full_unstemmed Lack of Toll-like Receptor 4 and 2 Polymorphisms in Korean Patients with Bacteremia
title_short Lack of Toll-like Receptor 4 and 2 Polymorphisms in Korean Patients with Bacteremia
title_sort lack of toll-like receptor 4 and 2 polymorphisms in korean patients with bacteremia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721950/
https://www.ncbi.nlm.nih.gov/pubmed/17179672
http://dx.doi.org/10.3346/jkms.2006.21.6.979
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